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Table 2 Detailed investigational results of lesional group

From: The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy

Patient No.

Age of epilepsy onset (years)

Age at investigation (years)

Time to presurgical evaluation (years)

Seizure type(s) and frequency

Localisation of epileptic focus according to clinical semiology and EEG findings

Neurocognitive deficit

Speech center lateralization defined by functional MRI

3 T MRI finding before the study

MRI findings in hybrid PET-MRI

FDG-PET/CT made before of our study (hypoMb)

FDG-PET findings in hybrid PET-MRI (hypoMb)

Additional information provided by PET comparing to MRI A, B, C, D, E, F, G

MR status change nn, np, nc, pp, pp+

Clinical decision according to PETMRI results

Outcome of iEEG and/or resective surgery outcome performed after our study

Time to resective surgery (years)

31.

16

38

22

Hypermotor, 15/month, 1 GM/year

R frontal R temporal L frontal L temporal

Left hemisphere.

Left

L cingular FCD or PMG

L cingular PMG

Not performed

R temporal L frontomedial

F

pp

2 - resective surgery is avalaible instead of iEEG

Resective surgery was performed in Oct. 2018, Engel II.

23

32.

18

28

10

Complex partial, 30/month, 1 GM/year

L temporal L insular

None.

N/A

L HS

L HS

Not performed

L temporal

G

pp

2 - resective surgery is avalaible instead of iEEG

Resective surgery was not yet performed

N/A

33.

7

40

33

Complex partial, 8/month, 1 GM/year

R frontal R temporal R insular L frontal L temporal L insular

Bilateral.

Left

L and right insular FCD

L and right insular FCD

Not performed

R temporal R frontolateral R insular L temporal

F

pp

1 - remained as iEEG candidate

iEEG and resective surgery was performed in 2016, Engel II.

33

34.

10

38

28

Complex partial, 3/month, 1 GM/year

R frontal R temporal L frontal L temporal

Bilateral.

N/A

L cingular FCD susp.

nonlesional

Not performed

R hemispherial

A

nc

5 - considered as not eligible for any further invasive procedures instead of resective surgery

N/A

N/A

35.

3

29

26

Hypermotor, 45/month, no GM

R frontal R temporal

Bilateral.

Left

R frontolateral FCD

R sulcus frontalis superior FCD

Not performed

R frontomedial R temporal L temporal

F

pp

6 - remained as candidate for resective surgery

Resective surgery was performed in Jun. 2018., Engel I.

27

36.

21

48

27

Complex partial, 4/month, 1 GM/year

R frontal R temporal L temporal

None.

N/A

L temporal FCD, susp.

R frontopolar heterotopia

Not performed

R frontomedial R temporal L temporal

F

pp+

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

37.

13

27

14

Complex partial, 10/month, no GM

R frontal R temporal L temporal

None.

Left

L frontolateral heterotopia, susp.

nonlesional

Not performed

R temporooccipital L temporooccipital

F

nc

3 - considered as not eligible for any further invasive procedures instead of iEEG

N/A

N/A

38.

11

22

11

Complex partial, 8/month, 1 GM/month

L frontal L insular L parietal

Bilateral.

N/A

L insular ischaemia

L HS L insular ischaemia

Not performed

L temporoinsular

C

pp+

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

39.

17

38

21

Hypermotor, 4/month, 1 GM/year

R frontal R insular

None.

N/A

R frontolateral FCD

R frontolateral FCD, bilateral occipital heterotopia

Not performed

R frontal

C

pp+

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

40.

3

34

31

Complex partial, 20/month, 1 GM/month

L frontal L insular

Left hemisphere.

Left

L HS

L HS

Negatíve

L temporoinsular

C

pp

1 - remained as iEEG candidate

iEEG (2018.) and resective surgery was performed in 2020., Engel II.

34

41.

38

41

3

Complex partial, 30/month, no GM

L temporal

None.

N/A

L temporal pole FCD

L temporal pole FCD

Not performed

R temporal L temporal

F

pp

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

42.

4

33

29

Hypermotor, 1–2/month, no GM

L frontal L insular

Left hemisphere.

Left

L precentral-opercular FCD

L precentral-opercular FCD

Not performed

L frontolateral L insular

D

pp

1 - remained as iEEG candidate

iEEG (2017.) and resective surgery was performed in 2017., Engel I.

30

43.

13

48

35

Complex partial, 6/month, 1 GM/year

R frontal R temporal L temporal

None.

N/A

L collateral sulcus FCD

Bilateral collateral sulcus FCD

Not performed

R frontal R temporal R parietal L frontal L temporal L parietal

F

pp+

3 - considered as not eligible for any further invasive procedures instead of iEEG

N/A

N/A

44.

25

39

14

Complex partial, 4/month, no GM

L temporal

None.

Left

L parahippocampal gyrus FCD

L parahippocampal gyrus FCD

Not performed

L temporal

C

pp

6 - remained as candidate for resective surgery

Resective surgery was not yet performed.

N/A

45.

14

25

11

Complex partial, 1–2/month, 1–3 GM/year

L temporal

Left hemisphere.

Left

L temporopolar FCD

L temporopolar FCD

Not performed

L temporal

C

pp

1 - remained as iEEG candidate

iEEG (2017.) and resective surgery was performed in 2017., Engel I.

11

46.

19

21

2

Complex partial, 2/month, 1 GM/year

L temporal L frontal

Left hemisphere.

N/A

L fusiform gyrus FCD

L fusiform gyrus FCD

Not performed

L temporooccipital

D

pp

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

47.

32

49

17

Complex partial, 5/month, 1 GM/year

R temporal L temporal

Left hemisphere.

Left

L amygdalar FCD

L amygdalar FCD

Not performed

L temporal

C

pp

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

48.

19

26

7

Hypermotor, 2/month, 1 GM/month

R frontal

None.

Left

L hippocampal oedema

nonlesional

Not performed

R frontolateral R temporal R insular

A

nc

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

49.

2

23

21

Complex partial, 2/month, no GM

R frontal R temporal R parietal

None.

Left

R temporal pole FCD

R temporal pole FCD

Not performed

R temporal L temporal

F

pp

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

50.

3

30

27

Complex partial, 4/month, 1 GM/month

L temporal L frontal

Bilateral.

Left

L mesiobasotemporal FCD

L cingular FCD, L temporal FCD

Left temporal

L frontomedial L temporal

C

pp+

1 - remained as iEEG candidate

iEEG was performed in 2016, patient did not concede to perform neither resective surgery nor neuromodulation.

27

51.

19

38

19

Complex partial, 5/month, 1 GM/year

R frontal R temporal R parietal L frontal L temporal L parietal

Left hemisphere.

N/A

L HS

L HS L posterior cingulate FCD

Not performed

R temporal L temporoparietal

F

pp+

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

52.

14

44

30

Complex partial, 3/month, 1 GM/month

R frontal R temporal

Bilateral.

Left

R HS

R HS

Not performed

R temporal

C

pp

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A

53.

14

24

10

Complex partial, 4/month, no GM

L frontal L temporal

None.

N/A

L hippocampal oedema

nonlesional

Not performed

R temporal L temporoparietal

B

nc

3 - considered as not eligible for any further invasive procedures instead of iEEG

N/A

N/A

54.

19

27

8

Complex partial, 8/month, 2 GM/month

L temporal

Left hemisphere.

Left

R collateral sulcus FCD

R collateral sulcus FCD

Not performed

L temporal

E

pp

1 - remained as iEEG candidate

iEEG (Febr. 2017.) and resective surgery was performed in Jun. 2017., Engel I.

9

55.

20

32

12

Complex partial, 8/month, no GM

R frontal R temporal L temporal

None.

N/A

R HS

R HS

Not performed

L hemispherial

E

pp+

3 - considered as not eligible for any further invasive procedures instead of iEEG

N/A

N/A

56.

18

29

11

Complex partial, 4/month, no GM

L temporooccipital L parietal

Bilateral.

Left

L HS

L parietotemporal PMG, heterotopia

Not performed

R temporoinsular L temporal

F

pp+

3 - considered as not eligible for any further invasive procedures instead of iEEG

N/A

N/A

57.

8

36

28

Complex partial, 7/month, 1 GM/year

R frontal L temporal

Bilateral.

Left

L HS

L HS

Not performed

R temporal

E

pp

3 - considered as not eligible for any further invasive procedures instead of iEEG

N/A

N/A

58.

6

20

14

Complex partial, 4/month, no GM

R frontal R temporoinsular

Bilateral.

Left

R temporal FCD

R HS, R uncus FCD

Not performed

R temporal R parietal

C

pp+

1 - remained as iEEG candidate

iEEG (2017) and resective surgery was performed in 2017, Engel II.

14

59.

21

57

36

Hypermotor, 8/month, no GM

R frontal R temporal

Right hemisphere.

Right

R frontolateral nodular heterotopia

R frontolateral nodular heterotopia

Not performed

R frontolateral hyperM

C

pp

2 - resective surgery is avalaible instead of iEEG

Resective surgery was performed in Nov. 2016, Engel II.

36

60.

18

32

14

Complex partial, 1/month, no GM

R parietal R insular L temporal L parietal L insular

None.

N/A

L HS

L HS

Not performed

L frontal L temporal

D

pp

1 - remained as iEEG candidate

iEEG was not yet performed.

N/A