Fig. 4

Mediation effects of baseline AD pathology on the associations of CSF HGF with cognitive function in non-demented participants. Results of mediation analyses suggested that 45.59% of the total association of the CSF HGF with the decline in MMSE scores (A), 51.59% of the total association of the CSF HGF with the decline in ADNI-MEM scores (B), and 42.75% of the total association with the decline in ADNI-EF scores (C), were attributed to baseline Aβ42. Moreover, 94.59% of the total association of the CSF HGF with the decline in MMSE scores (D), 89.52% of the total association of the CSF HGF with the decline in ADNI-MEM scores (E), and 58.54% of the total association with the decline in ADNI-EF scores (F), were attributed to baseline pTau. In addition, 93.33% of the total association of the CSF HGF with the decline in MMSE scores (G), 89.16% of the total association of the CSF HGF with the decline in ADNI-MEM scores (H), and 53.92% of the total association with the decline in ADNI-EF scores (I), were attributed to baseline tTau. All models were adjusted for age, sex, years of education, and APOE4 status