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Table 1 Demographic and clinical characteristics of all subjects

From: Different resting-state network disruptions in newly diagnosed drug-naïve Parkinson’s disease patients with mild cognitive impairment

Parameter PD, all HC PD-CU PD-MCI P1 P2 P3
Number, n 47 28 19 28
Handedness of writing (R: L) 47: 0 28: 0 19: 0 28:0
Age, y 55.00 ± 9.27 52.06 ± 7.00 54.88 ± 10.89 55.07 ± 8.20 0.085# 0.361 0.947#
Gender, M/F 23/24 8/20 8/11 15/13 0.083 0.164 0.440
Duration of disease, years 1.74 ± 1.61 1.87 ± 1.32 1.65 ± 1.80 0.288#
H & Y stage 1.87 ± 0.37 1.82 ± 0.58 1.000#
UPDRS score
Part I 0.79 ± 1.72 0.86 ± 1.21 0.448#
Part II 6.63 ± 3.18 6.21 ± 4.09 0.710
Part III 20.79 ± 7.44 19.79 ± 8.71 0.683
Part IV 0 0
NMSS score    21.95 ± 20.82 25.96 ± 21.73    0.380#
HDRS score 5.21 ± 6.87 6.79 ± 5.32 0.112#
HARS score 3.79 ± 4.88 5.68 ± 4.30 0.058#
MoCA score 27.89 ± 2.49 24.89 ± 3.28 0.002*
EDU, years 10.04 ± 4.01 10.29 ± 3.75 12.53 ± 3.03 8.36 ± 3.74 0.757# 0.001* < 0.001*#
  1. *Indicates significant difference;
  2. # Indicates the nonparametric test because of the non-normal distribution;
  3. 1 Comparison between all PD patients (PD-MCI and PD-CU) and HCs
  4. 2 Comparison among PD-MCI, PD-CU patients, and HCs
  5. 3 Comparison between PD-CU and PD-MCI patients
  6. Keys: PD Parkinson’s disease; HC healthy control; PD-CU PD patients with cognitive unimpaired; PD-MCI PD patients with mild cognitive impaired; R right; L left; M male; F female; H & Y Hoehn & Yahr; UPDRS unified PD rating scale; NMS non-motor symptoms; HDRS Hamilton depression rating scale; HARS Hamilton anxiety rating scale; MoCA Montreal cognitive assessment; EDU education