Table 1 baseline characteristics and demographics

Median age (IQR)-yr.

71(61–80)

70(61–80)

72(61–80)

0.518

Male sex- no. (%)

255(61.00)

124(62.31)

131(59.82)

0.602

  Medical history-no. (%)

  Previous ischemic stroke

50(11.96)

15(7.54)

35(15.98)

0.008

  History of atrial fibrillation

129(30.86)

53(26.63)

76(34.70)

0.074

  History of diabetes mellitus

103(24,64)

46(23.12)

57(26.03)

0.490

  History of hypertension

297(71.05)

140(70.35)

157(71.69)

0.763

  mRS score of 0 ~ 2 before stroke onset-no. (%)

392(93.78)

191(95.98)

201(91.78)

0.076

  Median glucose level at hospital arrival (IQR) -mmol/L

5.86(4.89–7.47)

6.01(4.96–7.51)

5.84(4.86–7.41)

0.660

Cause of stroke - no. (%)

0.380

  Intracranial atherosclerosis

172(41.15)

88(44.22)

84(38.36)

  Cardioembolism

138(33.01)

67(33.67)

71(32.42)

  Small-vessel occlusion

78(18.66)

31(15.58)

47(21.46)

  Undetermined

30(7.18)

13(6.53)

17(7.76)

Median duration (IQR)-min

  From stroke onset to hospital admission

100(60–155)

120(60–160)

90(55–150)

0.025

  From hospital admission to intravenous alteplase

30(23–40)

25(17–35)

36(28–45)

< 0.001

  From stroke onset to intravenous alteplase

135(95–191)

140(95–190)

135(95–192)

0.692

NIHSS score

  Median NIHSS score (IQR) before IVT

11(7–14)

11(7–14)

11(7–14)

0.999

  Median NIHSS score (IQR) at 1 h after IVT

9(5–14)

8(5–14)

9(5–14)

0.270

  Median NIHSS score (IQR) at 24 h after IVT

6(4–12)

6(3–11)

7(4–13)

0.198

  Median NIHSS score (IQR) at 3d after IVT

5(2–11)

5(2–10)

5(2–11)

0.403

  Median NIHSS score (IQR) at7d after IVT

4(1–9)

4(1–8)

3(1–9)

0.700

  Treated with embolectomy no. (%)

145(34.69)

73(36.68)

72(32.88)

0.414