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Table 2 Outcome measures of patients with AF versus without AF

From: Endovascular treatment for acute ischemic stroke in patients with versus without atrial fibrillation: a matched-control study

Outcome variables

Pre-matched population (n = 1755)

Post-matched population (n = 814)

With AF

(n = 550)

Without AF

(n = 1205)

Univariable analysis

With AF

(n = 407)

Without AF

(n = 407)

Univariable analysis

Effect size (95% CI)

P-value

Effect size (95% CI)

P-value

Primary outcome

mRS at 90 d, median (IQR)

4 (1–5)

3 (0–5)

0.59 (0.47–0.74) a

< 0.01

3 (0–5)

3 (1–5)

1. 16 (0.82–1.52) a

0.29

Secondary outcomes

 Successful recanalization after first attempt c

267/550 (48.6)

588/1205 (48.8)

0.99 (0.81–1. 21) b

0.92

209/407 (51.4)

190/407 (46.7)

1. 21 (0.92–1.59) b

0.18

 Successful recanalization after final attempt c

479/550 (87.1)

1065/1205 (88.4)

0.89 (0.65–1. 20) b

0.44

355/407 (87.2)

347/407 (85.3)

1. 18 (0.79–1.76) b

0.42

 Complete recanalization after final attempt d

376/550 (68.4)

789/1205 (65.5)

1. 14 (0.92–1.41) b

0. 24

279/407 (68.6)

264/407 (64.9)

1. 18 (0.88–1.58) b

0.27

 mRS 0–1 at 90 d

174/518 (33.6)

521/1162 (44.8)

0.62 (0.50–0.77) b

< 0.01

143/387 (37.0)

143/386 (37.1)

1.00 (0.74–1.33) b

0.98

 mRS 0–2 at 90 d

195/518 (37.6)

565/1162 (48.6)

0.64 (0.52–0.79) b

< 0.01

160/387 (41.3)

155/386 (40.2)

1.05 (0.79–1.40) b

0.74

 mRS 0–3 at 90 d

252/518 (48.7)

676/1162 (58.2)

0.68 (0.55–0.84) b

< 0.01

208/387 (53.8)

192/386 (49.7)

1. 17 (0.89–1.56) b

0.27

Safety outcomes

 Intra-procedural complications e

63/550 (11.5)

95/1205 (7.9)

1.51 (1.08–2. 12) b

0.02

43/407 (10.6)

36/407 (8.8)

1. 22 (0.76–1.94) b

0.41

 Any ICH within 24 h

158/516 (30.6)

222/1163 (19.1)

1.87 (1.48–2.37) b

< 0.01

106/384 (27.6)

95/388 (24.5)

1. 18 (0.85–1.62) b

0.32

 PH2 within 24 h f

35/516 (6.8)

41/1163 (3.5)

1.99 (1. 25-3. 17) b

< 0.01

25/384 (6.5)

23/388 (5.9)

1. 11 (0.62–1.98) b

0.74

 Symptomatic ICH within 24 h f

54/513 (10.5)

70/1156 (6.1)

1.83 (1. 26-2.65) b

< 0.01

36/381 (9.4)

35/386 (9.1)

1.05 (0.64–1.71) b

0.86

 Death within 90 d

100/518 (19.3)

162/1162 (13.9)

1.48 (1. 12-1.94) b

0.01

63/387 (16.3)

71/386 (18.4)

0.86 (0.59–1. 25) b

0.44

  1. Abbreviations: AF atrial fibrillation, CI confidence interval, ICH intracranial hemorrhage, IQR interquartile range, mRS modified Rankin Scale, mTICI modified Thrombolysis in Cerebral Infarction, OR odds ratio, PH2 parenchymal hematoma type 2
  2. Data are shown as the event number/total number (%), unless otherwise indicated
  3. aThe common OR values were calculated using an ordinal logistic regression model and indicated the odds of improvement of 1 point on the mRS at 90 days
  4. bThe OR values were calculated using a binary logistic regression model
  5. cDefined as mTICI of 2b-3
  6. dDefined as mTICI of 3
  7. eIncluding new territorial embolization, arterial perforation, arterial dissection, vasospasm requiring treatment and in-stent thrombosis
  8. fccording to the Heidelberg Bleeding Classification