Table 4 Clinical outcomes after shunt placement in patients with iNPH
Variables | Preserved DMN connectivity group (n = 13) | Reduced DMN connectivity group (n = 7) | Between-group comparison of change | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Baseline | Post-op | Change | P value | Baseline | Post-op | Change | P value | P value |
iNPHGS | |||||||||
 Gait | 2.0, 1–3 | 1.0, 0–2 | -1.0, -1-0 | 0.008 | 2.0, 0–3 | 1.0, 0–2 | -1.0, -1-0 | 0.046 | 0.938 |
 Cognition | 2.0, 1–3 | 2.0, 1–2 | 0.0, -1-0 | 0.083 | 3.0, 2–3 | 3.0, 2–3 | 0.0, 0–0 | 1.000 | 0.327 |
 Urination | 1.0, 0–3 | 1.0, 0–2 | 0.0, -1-0 | 0.014 | 2.0, 0–3 | 2.0, 0–3 | 0.0, -1-1 | 1.000 | 0.519 |
 Total | 5.0, 2–8 | 4.0, 2–6 | -1.0, -2-0 | 0.002 | 7.0, 2–8 | 7.0, 2–8 | 0.0, -2-0 | 0.102 | 0.281 |
MMSE (/30) | 25.0, 13–29 | 28.0, 18–30 | 2.0, 0–5 | 0.003 | 23.0, 11–27 | 21.0, 15–26 | 0.0, -3-9 | 0.752 | 0.072 |
FAB (/18) | 13.0, 9–15 | 15.0, 11–16 | 2.0, -1-4 | 0.006 | 11.0, 5–16 | 10.0, 4–14 | -1.0, -2-2 | 0.279 | 0.007 |
RAVLT | |||||||||
 Immediate recall (/75) | 25.0, 14–41 | 28.0, 14–43 | 3.0, -6-8 | 0.035 | 18.0, 6–24 | 17.0, 5–22 | -1.0, -4-2 | 0.288 | 0.011 |
 Delayed recall (/15) | 2.0, 0–9 | 5.0, 0–10 | 2.0, -1-4 | 0.008 | 0.0, 0–3 | 0.0, 0–4 | 0.0, -1-2 | 0.414 | 0.122 |
 Recognition (/30) | 27.0, 20–30 | 28.0, 22–30 | 1.0, -2-4 | 0.026 | 21.0, 14–25 | 18.0, 14–27 | -1.0, -4-4 | 0.527 | 0.037 |
TUG | |||||||||
 Completion time (seconds) | 12.4, 7.2–53.7 | 10.1, 7.0-20.4 | -1.6, -33.5-1.4 | 0.011 | 16.9, 8.4–50.2 | 12.3, 9.0-22.4 | -1.7, -27.8-2.6 | 0.128 | 0.906 |
 Number of steps | 22.0, 14–81 | 19.0, 14–40 | -3.0, -49.0-0 | 0.005 | 21.0, 16–62 | 19.0, 17–30 | -32.0-2 | 0.102 | 0.968 |