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Table 6 Allele and genotype distribution of the patients with partial response and failure to sodium channel blocking antiseizure medications

From: Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Gene

SNPs

Genotypes

Alleles

 

Partial response (n = 23)

Failure (n = 68)

 

Partial response A:B; failure A:B

Odds ratio (95% CI)

P*

A/B

AA

AB

BB

AA

AB

BB

p

SCN1A

rs121918808

C/T

22

1

0

68

0

0

0.2527

45:1; 136:0

 

0.2527

 

rs200176684

C/T

23

0

0

68

0

0

1.0000

46:0; 136:0

 

1.0000

 

rs201985242

G/C

23

0

0

67

1

0

1.0000

46:0; 135:1

 

1.0000

SCN1B

rs55742440

T/C

12

9

2

35

26

7

0.9753

33:13; 96:40

0.946 (0.451–1.982)

0.8875

 

rs3746255

C/T

21

2

0

64

4

0

0.6403

44:2; 132:4

1.500 (0.266–8.473)

0.4743

 

rs67486287

G/C

13

9

1

44

19

5

0.6175

35:11; 107:29

1.160 (0.525–2.560)

0.7184

 

rs67701503

C/A

13

9

1

44

19

5

0.6175

35:11; 107:29

1.160 (0.525–2.560)

0.7184

 

rs2305748

C/T

13

9

1

44

19

5

0.6175

35:11; 107:29

1.160 (0.525–2.560)

0.7184

 

rs369032304

G/A

23

0

0

67

1

0

1.0000

46:0; 135:1

 

1.0000

 

rs72558026

G/A

22

1

0

64

4

0

1.0000

45:1; 132:4

0.733 (0.080–6.734)

1.0000

SCN2A

rs2060198

T/A

23

0

0

64

3

1

0.6765

46:0; 131:5

 

0.3321

 

rs17183814

G/A

17

6

0

45

21

2

0.8849

40:6; 111:25

0.666 (0.255–1.742)

0.4061

 

rs138497939

A/C

23

0

0

68

0

0

1.0000

46:0; 136:0

 

1.0000

 

rs185590667

T/C

23

0

0

68

0

0

1.0000

46:0; 136:0

 

1.0000

 

rs199925238

G/A

21

2

0

63

5

0

1.0000

44:2; 131:5

 

1.0000

 

rs186154973

G/A

23

0

0

68

0

0

1.0000

46:0; 136:0

 

1.0000

SCN9A

rs9646771

T/C

13

7

3

48

12

8

0.3272

33:13; 108:28

1.520 (0.707–3.264)

0.2814

 

rs3750904

T/C

18

5

0

51

15

2

1.0000

41:5; 117:19

0.751 (0.263–2.140)

0.5902

 

rs199756028

G/A

23

0

0

68

0

0

1.0000

46:0; 136:0

 

1.0000

 

rs200613417

A/T

23

0

0

67

1

0

1.0000

46:0; 135:1

 

1.0000

 

rs200956485

G/A

23

0

0

68

0

0

1.0000

46:0; 136:0

 

1.0000

  1. Abbreviations: CI confidence interval, SNP single nucleotide polymorphism
  2. * The significance level is set to be 0.0024 or less using Bonferroni correction