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Table 6 Allele and genotype distribution of the patients with partial response and failure to sodium channel blocking antiseizure medications

From: Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Gene SNPs Genotypes Alleles
  Partial response (n = 23) Failure (n = 68)   Partial response A:B; failure A:B Odds ratio (95% CI) P*
A/B AA AB BB AA AB BB p
SCN1A rs121918808 C/T 22 1 0 68 0 0 0.2527 45:1; 136:0   0.2527
  rs200176684 C/T 23 0 0 68 0 0 1.0000 46:0; 136:0   1.0000
  rs201985242 G/C 23 0 0 67 1 0 1.0000 46:0; 135:1   1.0000
SCN1B rs55742440 T/C 12 9 2 35 26 7 0.9753 33:13; 96:40 0.946 (0.451–1.982) 0.8875
  rs3746255 C/T 21 2 0 64 4 0 0.6403 44:2; 132:4 1.500 (0.266–8.473) 0.4743
  rs67486287 G/C 13 9 1 44 19 5 0.6175 35:11; 107:29 1.160 (0.525–2.560) 0.7184
  rs67701503 C/A 13 9 1 44 19 5 0.6175 35:11; 107:29 1.160 (0.525–2.560) 0.7184
  rs2305748 C/T 13 9 1 44 19 5 0.6175 35:11; 107:29 1.160 (0.525–2.560) 0.7184
  rs369032304 G/A 23 0 0 67 1 0 1.0000 46:0; 135:1   1.0000
  rs72558026 G/A 22 1 0 64 4 0 1.0000 45:1; 132:4 0.733 (0.080–6.734) 1.0000
SCN2A rs2060198 T/A 23 0 0 64 3 1 0.6765 46:0; 131:5   0.3321
  rs17183814 G/A 17 6 0 45 21 2 0.8849 40:6; 111:25 0.666 (0.255–1.742) 0.4061
  rs138497939 A/C 23 0 0 68 0 0 1.0000 46:0; 136:0   1.0000
  rs185590667 T/C 23 0 0 68 0 0 1.0000 46:0; 136:0   1.0000
  rs199925238 G/A 21 2 0 63 5 0 1.0000 44:2; 131:5   1.0000
  rs186154973 G/A 23 0 0 68 0 0 1.0000 46:0; 136:0   1.0000
SCN9A rs9646771 T/C 13 7 3 48 12 8 0.3272 33:13; 108:28 1.520 (0.707–3.264) 0.2814
  rs3750904 T/C 18 5 0 51 15 2 1.0000 41:5; 117:19 0.751 (0.263–2.140) 0.5902
  rs199756028 G/A 23 0 0 68 0 0 1.0000 46:0; 136:0   1.0000
  rs200613417 A/T 23 0 0 67 1 0 1.0000 46:0; 135:1   1.0000
  rs200956485 G/A 23 0 0 68 0 0 1.0000 46:0; 136:0   1.0000
  1. Abbreviations: CI confidence interval, SNP single nucleotide polymorphism
  2. * The significance level is set to be 0.0024 or less using Bonferroni correction