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Table 7 Allele and genotype distribution of patients with response and not achieving seizure free to predominant sodium channel blocking antiseizure medications

From: Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Gene SNPs Genotypes Alleles
  Response (n = 58) Not seizure-free (n = 24)   Response A:B; not seizure-free A:B Odds ratio (95% CI) P*
A/B AA AB BB AA AB BB p
SCN1A rs121918808 C/T 57 1 0 24 0 0 1.0000 115:1; 48:0   1.0000
  rs200176684 C/T 57 0 1 24 0 0 1.0000 114:2; 48:0   0.5834
  rs201985242 G/C 58 0 0 24 0 0 1.0000 116:0; 48:0   1.0000
SCN1B rs55742440 T/C 40 17 1 12 8 4 0.0310 97:19; 32:16 0.392 (0.180–0.851) 0.0159
  rs3746255 C/T 57 1 0 22 2 0 0.2036 115:1; 46:2 0.2 (0.017–2.260) 0.2052
  rs67486287 G/C 41 16 1 17 5 2 0.3292 98:18; 39:9 0.796 (0.330–1.923) 0.6101
  rs67701503 C/A 41 16 1 17 5 2 0.3292 98:18; 39:9 0.796 (0.330–1.923) 0.6101
  rs2305748 C/T 41 16 1 17 5 2 0.3292 98:18; 39:9 0.796 (0.330–1.923) 0.6101
  rs369032304 G/A 58 0 0 24 0 0 1.0000 116:0; 48:0   1.0000
  rs72558026 G/A 57 1 0 20 4 0 0.0241 115:1; 44:4 0.096 (0.010–0.880) 0.0261
SCN2A rs2060198 T/A 54 4 0 24 0 0 0.3158 112:4; 48:0   0.3222
  rs17183814 G/A 41 14 3 14 9 1 0.4452 96:20; 37:11 0.701 (0.306–1.603) 0.5110
  rs138497939 A/C 57 1 0 24 0 0 1.0000 115:1; 48:0   1.0000
  rs185590667 T/C 57 1 0 24 0 0 1.0000 115:1; 48:0   1.0000
  rs199925238 G/A 54 4 0 21 3 0 0.4418 112:4; 45:3 0.536 (0.115–2.490) 0.6746
  rs186154973 G/A 57 1 0 24 0 0 1.0000 115:1; 48:0   1.0000
SCN9A rs9646771 T/C 39 12 7 14 5 5 0.5625 90:26; 33:15 0.636 (0.300–1.346) 0.2351
  rs3750904 T/C 44 11 3 18 6 0 0.6353 99:17; 42:6 1.202 (0.433–3.261) 0.7184
  rs199756028 G/A 57 1 0 24 0 0 1.0000 115:1; 48:0   1.0000
  rs200613417 A/T 58 0 0 23 1 0 0.2926 116:0; 47:1   0.2927
  rs200956485 G/A 57 1 0 24 0 0 1.0000 115:1; 48:0   1.0000
  1. Abbreviations: CI confidence interval, SNP single nucleotide polymorphism
  2. * The significance level is set to be 0.0024 or less using Bonferroni correction