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Table 8 Allele and genotype distribution of patients with partial response and failure to predominant sodium channel blocking antiseizure medications

From: Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Gene

SNPs

Genotypes

Alleles

 

Partial response (n = 5)

Failure (n = 19)

 

Partial response A:B; failure A:B

Odds ratio (95% CI)

p*

A/B

AA

AB

BB

AA

AB

BB

p

SCN1A

rs121918808

C/T

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

 

rs200176684

C/T

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

 

rs201985242

G/C

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

SCN1B

rs55742440

T/C

2

2

1

10

6

3

1.0000

6:4; 26:12

1.444 (0.342–6.086)

0.7118

 

rs3746255

C/T

5

0

0

17

2

0

1.0000

10:0; 36:2

 

1.0000

 

rs67486287

G/C

2

3

0

15

2

2

0.0785

7:3; 32:6

2.286 (0.457–11.426)

0.3698

 

rs67701503

C/A

2

3

0

15

2

2

0.0785

7:3; 32:6

2.286 (0.457–11.426)

0.3698

 

rs2305748

C/T

2

3

0

15

2

2

0.0785

7:3; 32:6

2.286 (0.457–11.426)

0.3698

 

rs369032304

G/A

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

 

rs72558026

G/A

5

0

0

15

4

0

0.5440

10:0; 34:4

 

0.5665

SCN2A

rs2060198

T/A

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

 

rs17183814

G/A

2

3

0

12

6

1

0.4797

7:3; 30:8

1.607 (0.337–7.658)

0.6754

 

rs138497939

A/C

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

 

rs185590667

T/C

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

 

rs199925238

G/A

4

1

0

17

2

0

0.5212

9:1; 36:2

2.000 (0.163–24.590)

1.0000

 

rs186154973

G/A

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

SCN9A

rs9646771

T/C

0

3

2

14

2

3

0.0092

3:7; 30:8

8.75 (1.836–41.693)

0.0059

 

rs3750904

T/C

4

1

0

14

5

0

1.0000

9:1; 33:5

0.733 (0.076–7.099)

1.0000

 

rs199756028

G/A

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

 

rs200613417

A/T

5

0

0

18

1

0

1.0000

10:0; 37:1

 

1.0000

 

rs200956485

G/A

5

0

0

19

0

0

1.0000

10:0; 38:0

 

1.0000

  1. Abbreviations: CI confidence interval, SNP single nucleotide polymorphism
  2. * The significance level is set to be 0.0024 or less using Bonferroni correction