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Table 8 Allele and genotype distribution of patients with partial response and failure to predominant sodium channel blocking antiseizure medications

From: Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Gene SNPs Genotypes Alleles
  Partial response (n = 5) Failure (n = 19)   Partial response A:B; failure A:B Odds ratio (95% CI) p*
A/B AA AB BB AA AB BB p
SCN1A rs121918808 C/T 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  rs200176684 C/T 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  rs201985242 G/C 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
SCN1B rs55742440 T/C 2 2 1 10 6 3 1.0000 6:4; 26:12 1.444 (0.342–6.086) 0.7118
  rs3746255 C/T 5 0 0 17 2 0 1.0000 10:0; 36:2   1.0000
  rs67486287 G/C 2 3 0 15 2 2 0.0785 7:3; 32:6 2.286 (0.457–11.426) 0.3698
  rs67701503 C/A 2 3 0 15 2 2 0.0785 7:3; 32:6 2.286 (0.457–11.426) 0.3698
  rs2305748 C/T 2 3 0 15 2 2 0.0785 7:3; 32:6 2.286 (0.457–11.426) 0.3698
  rs369032304 G/A 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  rs72558026 G/A 5 0 0 15 4 0 0.5440 10:0; 34:4   0.5665
SCN2A rs2060198 T/A 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  rs17183814 G/A 2 3 0 12 6 1 0.4797 7:3; 30:8 1.607 (0.337–7.658) 0.6754
  rs138497939 A/C 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  rs185590667 T/C 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  rs199925238 G/A 4 1 0 17 2 0 0.5212 9:1; 36:2 2.000 (0.163–24.590) 1.0000
  rs186154973 G/A 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
SCN9A rs9646771 T/C 0 3 2 14 2 3 0.0092 3:7; 30:8 8.75 (1.836–41.693) 0.0059
  rs3750904 T/C 4 1 0 14 5 0 1.0000 9:1; 33:5 0.733 (0.076–7.099) 1.0000
  rs199756028 G/A 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  rs200613417 A/T 5 0 0 18 1 0 1.0000 10:0; 37:1   1.0000
  rs200956485 G/A 5 0 0 19 0 0 1.0000 10:0; 38:0   1.0000
  1. Abbreviations: CI confidence interval, SNP single nucleotide polymorphism
  2. * The significance level is set to be 0.0024 or less using Bonferroni correction