Table 1 Baseline characteristics of included patients according to the level of serum total bilirubin
Variable | Overall | Quartile of total bilirubin, μmol/L | P value | |||
|---|---|---|---|---|---|---|
Q1(<9.90) | Q2 (9.90-13.28) | Q3 (13.28-17.67) | Q4 (≥17.67) | |||
n | 11121 | 2797 | 2746 | 2791 | 2787 | |
Age, y | 63.00(54.00-70.00) | 62.00(54.00-70.00) | 63.00(54.00-70.00) | 63.00(54.00-70.00) | 63.00(55.00-71.00) | 0.1924 |
Men, n (%) | 7569 (68.06) | 1676 (59.92) | 1793 (65.29) | 1967 (70.48) | 2133 (76.53) | <0.0001 |
BMI, kg/m2 | 24.47(22.49-26.42) | 24.34(22.49-26.35) | 24.44(22.58-26.37) | 24.49(22.76-26.49) | 24.49(22.49-26.45) | 0.1316 |
Current smoker | 3488 (31.36) | 869 (31.07) | 862 (31.39) | 873 (31.28) | 884 (31.72) | 0.0001 |
Medical History, n (%) | ||||||
Hypertension | 6958 (62.57) | 1765 (63.10) | 1717 (62.53) | 1727 (61.88) | 1749 (62.76) | 0.8123 |
Diabetes mellitus | 2572 (23.13) | 751 (26.85) | 644 (23.45) | 640 (22.93) | 537 (19.27) | <0.0001 |
Dyslipidemia | 858 (7.72) | 218 (7.79) | 227 (8.27) | 219 (7.85) | 194 (6.96) | 0.3218 |
Stroke or TIA | 2525 (22.70) | 681 (24.35) | 624 (22.72) | 606 (21.71) | 614 (22.03) | 0.0863 |
Atrial fibrillation/flutter | 743 (6.68) | 97 (3.47) | 132 (4.81) | 181 (6.49) | 333 (11.95) | <0.0001 |
Peripheral vascular disease | 76 (0.68) | 25 (0.89) | 18 (0.66) | 17 (0.61) | 16 (0.57) | 0.4621 |
Heart failure | 68 (4.39) | 12 (3.46) | 11 (3.09) | 19 (4.91) | 26 (5.68) | 0.2402 |
Stroke type/Subtype, n (%) | ||||||
Ischemic stroke | 10339 (92.97) | 2554 (91.31) | 2530 (92.13) | 2617 (93.77) | 2638 (94.65) | <0.0001 |
TIA | 782 (7.03) | 243 (8.69) | 216 (7.87) | 174 (6.23) | 149 (5.35) | |
TOAST, n (%) | ||||||
Large-artery atherosclerosis | 2811 (25.28) | 717 (25.63) | 674 (24.54) | 718 (25.73) | 702 (25.19) | <0.0001 |
Cardioembolism | 662 (5.95) | 113 (4.04) | 130 (4.73) | 150 (5.37) | 269 (9.65) | |
Small-vessel occlusion | 2319 (20.85) | 578 (20.66) | 590 (21.49) | 627 (22.47) | 524 (18.80) | |
Other determined etiology | 149 (1.34) | 56 (2.00) | 26 (0.95) | 27 (0.97) | 40 (1.44) | |
Undetermined etiology | 5180 (46.58) | 1333 (47.66) | 1326 (48.29) | 1269 (45.47) | 1252 (44.92) | |
Medication in hospital, n (%) | ||||||
Cholesterol-lowering agents | 10613 (96.12) | 2656 (95.51) | 2629 (96.51) | 2650 (95.77) | 2678 (96.71) | 0.0584 |
Antihypertensive agents | 5052 (45.76) | 1253 (45.06) | 1223 (44.90) | 1277 (46.15) | 1299 (46.91) | 0.3879 |
Hypoglycemic agents | 2751 (24.92) | 747 (26.86) | 688 (25.26) | 696 (25.15) | 620 (22.39) | 0.0016 |
Antiplatelet agents | 10723 (97.12) | 2730 (98.17) | 2662 (97.72) | 2679 (96.82) | 2652 (95.77) | <0.0001 |
Anticoagulant agents | 1097 (9.94) | 262 (9.42) | 229 (8.41) | 247 (8.93) | 359 (12.96) | <0.0001 |
NIHSS score on admission | 3(1-6) | 3(1-5) | 3(1-5) | 3(1-6) | 4(2-7) | <0.0001 |
Laboratory tests | ||||||
TC, mmol/L | 4.00(3.33-4.74) | 3.94(3.26-4.71) | 3.99(3.32-4.72) | 4.01(3.35-4.77) | 4.03(3.37-4.77) | 0.0412 |
LDL, mmol/L | 2.34(1.74-3.00) | 2.33(1.75-2.97) | 2.31(1.73-3.01) | 2.35(1.76-2.99) | 2.36(1.73-3.04) | 0.5899 |
HDL, mmol/L | 0.93(0.77-1.12) | 0.94(0.78-1.15) | 0.94(0.79-1.11) | 0.93(0.77-1.11) | 0.91(0.76-1.10) | 0.0028 |
TG, mmol/L | 1.36(1.03-1.87) | 1.29(0.99-1.74) | 1.33(1.02-1.82) | 1.42(1.06-1.95) | 1.44(1.09-2.02) | <0.0001 |
FBG, mmol/L | 5.51(4.89-6.88) | 5.51(4.89-6.95) | 5.50(4.89-6.81) | 5.53(4.90-6.95) | 5.51(4.88-6.82) | 0.5578 |
eGFR, mL/min/1.73 m2 | 92.99(81.39-101.75) | 93.72(79.48-102.24) | 92.62(80.80-101.14) | 93.06(82.93-101.74) | 92.73(82-101.91) | 0.2971 |
hs-CRP, mg/L | 1.76(0.80-4.71) | 1.75(0.86-4.63) | 1.64(0.77-4.25) | 1.72(0.79-4.53) | 1.90(0.82-5.72) | 0.0008 |
ALT, U/L | 18.00(13.00-25.80) | 17.00(12.00-24.00) | 18.00(13.00-25.00) | 18.00(13.00-26.00) | 19.00(14.00-27.00) | <0.0001 |
AST, U/L | 19.00(16.00-24.00) | 18.05(15.00-23.00) | 19.00(15.30-24.00) | 19.40(16.00-24.00) | 20.10(17.00-26.00) | <0.0001 |