Table 2 Adjusted odds ratio (95% confidence interval) for poor functional outcomes according to serum bilirubin levels

TBIL

mRS score 2-6

Quartile 1

634 (22.67)

Reference

Reference

591 (21.13)

Reference

Reference

Quartile 2

692 (25.20)

1.19(1.05-1.36)

1.14(0.99-1.32)

620 (22.58)

1.14(0.99-1.30)

1.09(0.95-1.26)

Quartile 3

759 (27.19)

1.34(1.18-1.53)

1.31(1.14-1.52)

658 (23.58)

1.21(1.06-1.39)

1.17(1.01-1.35)

Quartile 4

860 (30.86)

1.53(1.35-1.74)

1.37(1.19-1.59)

788 (28.27)

1.51(1.32-1.72)

1.31(1.13-1.52)

P for trend

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

mRS score 3-6

Quartile 1

323 (11.55)

Reference

Reference

319 (11.41)

Reference

Reference

Quartile 2

361 (13.15)

1.19(1.01-1.41)

1.13(0.95-1.36)

338 (12.31)

1.13(0.95-1.34)

1.04(0.87-1.25)

Quartile 3

405 (14.51)

1.35(1.14-1.59)

1.29(1.08-1.54)

370 (13.26)

1.27(1.08-1.50)

1.18(0.98-1.42)

Quartile 4

492 (17.65)

1.58(1.35-1.86)

1.33(1.11-1.59)

471 (16.90)

1.59(1.35-1.87)

1.28(1.07-1.53)

P for trend

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

DBIL

mRS score 2-6

Quartile 1

625 (23.05)

Reference

Reference

569 (20.98)

Reference

Reference

Quartile 2

701 (25.09)

1.15(1.01-1.32)

1.13(0.97-1.31)

607 (21.73)

1.10(0.96-1.26)

1.05(0.90-1.22)

Quartile 3

766 (26.62)

1.26(1.10-1.45)

1.18(1.01-1.38)

699 (24.30)

1.33(1.15-1.53)

1.21(1.04-1.42)

Quartile 4

853 (31.15)

1.61(1.40-1.86)

1.38(1.17-1.62)

782 (28.56)

1.69(1.47-1.95)

1.37(1.17-1.61)

P for trend

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

mRS score 3-6

Quartile 1

297 (10.95)

Reference

Reference

284 (10.47)

Reference

Reference

Quartile 2

376 (13.46)

1.33(1.12-1.59)

1.29(1.07-1.56)

336 (12.03)

1.23(1.03-1.47)

1.12(0.92-1.35)

Quartile 3

399 (13.87)

1.39(1.16-1.66)

1.29(1.06-1.56)

390 (13.56)

1.44(1.20-1.72)

1.23(1.01-1.49)

Quartile 4

509 (18.59)

1.98(1.66-2.37)

1.59(1.30-1.94)

488 (17.82)

1.97(1.64-2.36)

1.40(1.14-1.71)

P for trend

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

IBIL

mRS score 2-6

Quartile 1

641 (23.30)

Reference

Reference

597 (21.70)

Reference

Reference

Quartile 2

709 (25.44)

1.14(1.00-1.30)

1.10(0.95-1.27)

638 (22.89)

1.07(0.94-1.22)

1.03(0.90-1.20)

Quartile 3

769 (27.46)

1.32(1.15-1.50)

1.26(1.09-1.46)

675 (24.11)

1.19(1.04-1.36)

1.13(0.97-1.31)

Quartile 4

826 (29.68)

1.42(1.24-1.62)

1.30(1.12-1.51)

747 (26.84)

1.35(1.18-1.55)

1.21(1.04-1.41)

P for trend

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

mRS score 3-6

Quartile 1

329 (11.96)

Reference

Reference

337 (12.25)

Reference

Reference

Quartile 2

385 (13.81)

1.18(1.00-1.39)

1.15(0.96-1.38)

362 (12.99)

1.07(0.91-1.26)

1.03(0.86-1.23)

Quartile 3

398 (14.21)

1.26(1.07-1.49)

1.21(1.01-1.45)

353 (12.61)

1.08(0.91-1.28)

1.00(0.83-1.20)

Quartile 4

469 (16.85)

1.48(1.25-1.75)

1.31(1.09-1.57)

446 (16.03)

1.43(1.21-1.69)

1.23(1.02-1.48)

P for trend

<0.0001

<0.0001

<0.0001

0.0002

<0.0001

<0.0001