Skip to main content

Table 3 Reclassification and discrimination statistics for outcomes within 90 days and 1 year by serum bilirubin

From: Serum bilirubin levels are associated with poor functional outcomes in patients with acute ischemic stroke or transient ischemic attack

 

C statistic

IDI

Category-free NRI

Estimate (95% CI)

P value

Estimate (95% CI), %

P value

Estimate (95% CI), %

P value

Outcomes at 3 months

 mRS score 2-6

  Conventional modela

0.762(0.752-0.772)

 

Reference

 

Reference

 

  Conventional model+TBIL

0.763(0.753-0.773)

0.0437

2.07(1.10-3.00)

<0.0001

8.56(4.33-12.80)

<0.0001

  Conventional model+DBIL

0.762(0.753-0.773)

0.1089

2.12(1.20-3.10)

<0.0001

8.43(4.18-12.68)

0.0001

  Conventional model+IBIL

0.763(0.753-0.773)

0.0443

1.52(0.07-2.40)

0.0004

7.17(2.94-11.41)

0.0010

 mRS score 3-6

  Conventional modela

0.780(0.768-0.792)

 

Reference

 

Reference

 

  Conventional model+TBIL

0.782(0.770-0.794)

0.0252

2.44(1.10-3.70)

0.0003

10.53(5.15-15.90)

0.0001

  Conventional model+DBIL

0.782(0.770-0.794)

0.0432

4.50(2.70-6.30)

<0.0001

10.56(5.18-15.95)

0.0001

  Conventional model+IBIL

0.781(0.769-0.793)

0.0431

1.18(0.20-2.10)

0.0138

8.03(2.66-13.40)

0.0037

Outcomes at 1 year

 mRS score 2-6

  Conventional modela

0.738(0.727-0.749)

 

Reference

 

Reference

 

  Conventional model+TBIL

0.739(0.728-0.750)

0.0497

1.64(0.70-2.50)

0.0003

7.23(2.85-111.62)

0.0014

  Conventional model+DBIL

0.739(0.728-0.749)

0.1763

1.84(0.09-2.80)

0.0001

6.10(1.68-10.48)

0.0072

  Conventional model+IBIL

0.739(0.728-0.750)

0.0379

1.13(0.40-1.90)

0.0034

5.64(2.26-10.03)

0.0127

 mRS score 3-6

  Conventional modela

0.776(0.764-0.790)

 

Reference

 

Reference

 

  Conventional model+TBIL

0.778(0.765-0.791)

0.0667

1.82(0.06-3.10)

0.0040

6.16(0.69-11.63)

0.0239

  Conventional model+DBIL

0.779(0.766-0.792)

0.0319

3.79(2.00-5.60)

<0.0001

8.71(3.21-14.21)

0.0021

  Conventional model+IBIL

0.777(0.764-0.790)

0.1432

0.76(0.01-1.60)

0.0378

4.77(0.70-10.24)

0.0415

  1. Abbreviations: CI confidence interval, DBIL direct bilirubin, IBIL indirect bilirubin, IDI integrated discrimination improvement, mRS modified Rankin Scale, NRI net reclassification index, TBIL total bilirubin
  2. aAdjusted for age, sex, history of diabetes, atrial fibrillation/flutter, smoking status, stroke subtype, hypoglycemic agents, antiplatelet agents, baseline National Institutes of Health Stroke Scale score, total cholesterol, high density lipoprotein cholesterol, triglyceride, high sensitivity C-reactive protein, alanine aminotransferase and aspartate aminotransferase
Back to article page

BMC Neurology

ISSN: 1471-2377

Contact us