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Table 1 Characteristics of individual trials included in the meta-analysis

From: 3,4-diaminopyridine treatment for Lambert-Eaton myasthenic syndrome in adults: a meta-analysis of randomized controlled trials

Author

Year

Country

Study type

Study design

Cases

Age (year)

Female (%)

Cancer (%)

Treatment

QMG

CMAP

McEvoy

1989

USA

RCT

Cross-over

12

34–75

8(66.7 %)

7(58.3 %)

3,4-DAP

N/A

CMAP

Sanders

2000

USA

RCT

Parallel

26

41–68

15(57.7 %)

10(38.5 %)

3,4-DAP

QMG

CMAP

Oh

2009

USA

RCT

Cross-over

6

25–75

1(16.7)

2(33.3 %)

3,4-DAP

QMG

CMAP

Wirtz

2009

Netherlands

RCT

Cross-over

9

33–73

4(44.4 %)

N/A

3,4-DAP

N/A

CMAP

Oh

2016

USA

RCT

Parallel

36

21–88

23(63.9 %)

6(16.7 %)

3,4-DAP

QMG

CMAP

Shieh

2019

USA

RCT

Parallel

26

31–75

16(61.5 %)

6(23.1 %)

3,4-DAP

QMG

N/A

  1. N/A without data, QMG quantitative myasthenia gravis, CMAP compound muscle action potentials