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Table 2 Comparison of the outcomes in MC patients during mechanical ventilation

From: Hemogram parameters can predict in-hospital mortality of patients with Myasthenic crisis

 

During mechanical ventilation

Mortality

Survival

  

M_dMV (N = 26)

S_dMV (N = 139)

Crude p

OR (95%CI)

Adjusted p

Age at MC onset (years)

66.73 ± 15

52.42 ± 18.14

<0.001*

1.039 (1.006-1.074)

0.022*

Sex

 Female / Male

12 / 14

83 / 56

0.199

  

Underlying diseases [n (%)]

 Hypertension

3 (11.5)

36 (25.9)

0.136

  

 Diabetes mellitus

4 (15.4)

24 (17.3)

1.000

  

 Dyslipidemia

0 (0)

5 (3.6)

1.000

  

 COPD

0 (0)

3 (2.2)

1.000

  

 Liver cirrhosis

4 (15.4)

2 (1.4)

0.006*

6.19 (0.719-53.266)

0.097

 CRF

1 (3.8)

5 (3.6)

1.000

  

Medication for MG before admission [n (%)]

 Pyridostigmine only

5 (19.2)

24 (17.3)

0.809

  

 DMT with or without pyridostigmine

17 (65.4)

85 (61.2)

0.683

  

 Prednisolone monotherapy

11 (64.7)

50 (58.8)

0.080

  

 Immunosuppressant monotherapy

3 (17.6)

4 (4.7)

   

 Prednisolone + Immunosuppressant

3 (17.6)

31 (36.5)

   

 PE / DFPP [n (%)]

6 (23.1)

88 (63.3)

0.000*

0.236 (0.077-0.728)

0.012*

Hemogram in 3 days before intubation

 Hb (g/dL)

10.32 ± 2.7

12.66 ± 2.15

<0.001*

  

 Hb < 11 g/dL [n (%)]

16 (61.5)

30 (21.6)

<0.001*

5.851 (2.003-17.092)

0.001*

 Platelet (x 109/L)

140.88 ± 84.37

225.62 ± 106.56

<0.001*

  

 Platelet < 150 x 109/L [n (%)]

13 (50)

34 (24.5)

0.008*

1.045 (0.349-3.126)

0.937

 WBC (x 109/L)

16.83 ± 12.3

13.9 ± 7.7

0.250

  

 WBC≧25 x 109/L [n (%)]

5 (19.2)

9 (6.5)

0.032*

5.659 (1.28-25.023)

0.022*

 Neutrophil (%)

79.88 ± 17.32

82.18 ± 12.31

0.415

  

 Lymphocyte (%)

13.65 ± 15.99

12.03 ± 9.25

0.620

  

 NLR

20.2 ± 22.59

14.66 ± 20.83

0.221

  
  1. ѱ Abbreviations: COPD Chronic obstructive pulmonary disease, CRF Chronic renal failure, DMT Disease modified therapy, Hb Hemoglobin, MC Myasthenic crisis, M_dMV Mortality during mechanical ventilation, NLR Neutrophil-lymphocyte ratio, S_dMV Survival during mechanical ventilation, PE / DFPP Plasma exchange or double-filtration plasmapheresis, WBC White blood count