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Table 1 Demographic and clinical characteristics of patients without and with PSD

From: Higher fasting C-peptide is associated with post-stroke depression: a multicenter prospective cohort study

Parameter

NPSD(N = 420)

64%

PSD(N = 236)

36%

P

Demographic information

 Age, median (IQR)

58(51, 66)

60(52, 67)

0.143

 Females, n (%)

82(19.50)

66(28.00)

0.013*

 BMI, median (IQR)

24.45(22.50, 26.90)

24.20(22.50,26.73)

0.387

 hospitalization days, median (IQR)

10(8, 13)

11(8, 15)

0.002*

 Sleep time < 5 h, n (%)

44(10.50)

45(19.1)

0.002*

 Education level, n (%)

189(45.00)

79(33.50)

0.004*

 Smoking, n (%)

190(45.20)

99(41.90)

0.415

 Drinking, n (%)

195(46.40)

93(39.40)

0.082

 Hypertension, n (%)

249(59.30)

136(57.60)

0.679

 Diabetes mellitus, n(%)

120(28.60)

67(28.40)

0.961

 Hyperlipemia, n (%)

106(25.20)

73(30.90)

0.116

 CHD, n (%)

43(10.20)

26(10.50)

0.755

Serum biochemicals

 FCP, median (IQR)

1.82(1.14, 2, 49)

2.00(1.38, 2.70)

0.009*

 ACTH, median (IQR)

30.90(16.64, 44.43)

32.40(18.61,47.95)

0.229

 CRP, median (IQR)

1.80(0.80, 5.48)

2.50(0.93, 5.89)

0.087

 Cortical, median (IQR)

13.00(10.33, 15.70)

13.50(10.93,16.20)

0.077

 WBC, median (IQR)

6.57(5.39, 8.08)

6.89(5.66, 8.50)

0.037*

 NEU, median (IQR)

4.11(3.25, 5.46)

4.36(3.47, 5.80)

0.018*

 MONO, median (IQR)

0.50(0.39, 0.62)

0.53(0.44, 0.67)

0.006*

 LYM, median (IQR)

1.58(1.27, 2.09)

1.65(1.23, 1.99)

0.904

 IL.1β, median (IQR)

66.47(28.05, 165.07)

63.60(26.05,167.02)

0.894

 IL.6, median (IQR)

6.00(2.76,9.54)

6.00(2.60,10.06)

0.242

 IL.10, median (IQR)

9.13(2.89,22.96)

7.78(2.57,19.73)

0.286

 IL.18, median (IQR)

2158.84(1012.72,4753.75)

1896.82(954.22,4913.12)

0.439

 TNF-α, median (IQR)

37.11(21.85,57.62)

41.42(23.20,59.97)

0.260

 IFN-γ, median (IQR)

4.33(1.50,8.27)

5.10(2.00,9.72)

0.063

Clinical characteristics

 NIHSS, median (IQR)

2(1,5)

3(2,7)

<0.001*

 BI, median (IQR)

95(65,100)

80(40,100)

<0.001*

 MRS, median (IQR)

2(1,3)

2(1,4)

0.002*

 CD-RISC, median (IQR)

65(54,77)

61(50,73)

0.008*

 N, median (IQR)

8(4,11)

9(6,13)

0.027*

  1. PSD Post-stroke depression, IQR Interquartile range, BMI Body mass index, CHD Coronary heart disease, FCP Fasting C-peptide, ACTH Adrenocorticotropic hormone, CRP C-reactive protein, WBC White blood count, NEU Neutrophil count, LYM Lymphocyte count, MONO Monocyte count, IL Interleukin, TNF-α Tumor necrosis factor-α, IFN Interferon, NIHSS The National Institutes of Health Stroke Scale, BI Barthel Index, m RS Modified Rankin Scale, CD-RISC Conner-Davidson Resilience Scale, N Neuroticism
  2. *Statistically significant at p < 0.05 level, two-sided