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Fig. 3 | BMC Neurology

Fig. 3

From: The application of shotgun metagenomics to the diagnosis of granulomatous amoebic encephalitis due to Balamuthia mandrillaris: a case report

Fig. 3

Pathological findings of brain and skin biopsy samples. Histopathological findings of the brain biopsy (A, B, C and D), and the skin biopsy (E). A, hematoxylin and eosin (H&E) stained section showing necrotic tissue surrounded by palisading epithelioid histiocytes, forming epithelioid granuloma with necrosis (original magnification × 100). B, Multiple epithelioid granulomas without necrosis were also seen (H&E stain, original magnification × 200). C and D, Multinucleated giant cell containing an amoebic trophozoite (C, H&E stain, highlighted by yellow arrow) was detected, which was confirmed by immunohistochemical staining with anti-B. mandrillaris rabbit antibody (D, highlighted by yellow arrow) (original magnification × 400). E, Skin biopsy also showed multinucleated giant cells containing amoebic trophozoite (H&E stain, highlighted by yellow arrow, original magnification × 400)

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BMC Neurology

ISSN: 1471-2377

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