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Table 8 Predictors of relapse in NMOSD patients by univariate and multivariable Cox proportional hazards models

From: Association of neutrophil-to-lymphocyte ratio (NLR) with the prognosis of first attack neuromyelitis optica spectrum disorder (NMOSD): a retrospective cohort study

Variable

Univariate

 

Multivariate

 
 

HR (95% CI)

P value

HR (95% CI)

P value

Age, years

1.00(0.99,1.01)

0.916

  

Male sex, no. (%)

0.94(0.66,1.35)

0.738

  

Hypertension, no. (%)

1.70(1.12,2.57)

0.013

1.31(0.80,2.16)

0.282

Diabetes, no. (%)

0.76(0.34,1.73)

0.518

  

Initial EDSS

1.10(1.00,1.20)

0.03

1.05(0.94,1.16)

0.395

Anti-AQP4 antibody, no. (%)

1.43(0.95,2.13)

0.085

1.37(0.91,2.05)

0.127

LETM

0.89(0.55,1.45)

0.637

  

Corticosteroids, no. (%)

0.78(0.34,1.76)

0.545

  

Immunoglobulins, no. (%)

1.12(0.64,1.95)

0.686

  

Immunosuppressants, no. (%)

1.34(0.94,1.91)

0.112

  

NLR

1.05(1.03,1.08)

< 0.001

1.07(1.03,1.10)

0.001

PLR

1.00(0.99,1.02)

0.001

1.00(0.99,1.02)

0.881

LMR

1.01(0.98,1.04)

0.323

  

DMT

0.72 (0.43,1.18)

0.19

  
  1. EDSS Extended disability status scale, LMR Lymphocyte-to-monocyte technical ratio, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, LETM longitudinally extensive transverse myelitis, AQP4 aquaporin-4, DMT disease-modifying treatment started during the follow-up