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Table 1 Baseline characteristics of LHI patients before PSM

From: Early amantadine treatment reduces the risk of death in patients with large hemisphere infarctions:a Chinese hospital-based study

 

Amantadine

(n = 31)

ST

(n = 127)

P value

Age (years)

 Mean ± SD

70.68 ± 11.42

65.45 ± 15.32

0.077*

 Median (range)

76 (46–87)

68 (18–94)

0.061†

Female, n (%)

17 (54.83)

69 (54.33)

0.959‡

Time from onset (hours), median (range)

2 (1–24)

10 (1–24)

< 0.001†

NIHSS score on admission

21.71 ± 4.76

17.49 ± 5.84

< 0.001*

GCS score on adimission

9.35 ± 1.72

10.17 ± 3.06

0.158*

SBP on admission (mm Hg)

150.45 ± 20.48

140.17 ± 26.96

0.056*

DBP on admission (mm Hg)

87.71 ± 14.95

82.87 ± 16.84

0.145*

Serum glucose on admission (mmol/L)

7.72 ± 4.49

7.88 ± 3.25

0.822*

Risk factors, n (%)

 Hypertension

12 (38.71)

66 (51.97)

0.186‡

 Diabetes mellitus

6 (19.35)

27 (21.26)

0.815‡

 Dyslipidemia

6 (19.35)

20 (15.75)

0.627‡

 Coronary heart disease

8 (25.81)

21 (16.54)

0.232‡

 Atrial fibrillation

22 (70.97)

70 (55.12)

0.109‡

 Rheumatic heart disease

5 (16.13)

35 (27.56)

0.189‡

 Current smoking

10 (32.26)

26 (20.47)

0.161‡

 Alcohol consumption

3 (9.68)

19 (14.96)

0.446 ‡

 Previous all strokes/TIA

9 (29.03)

26 (20.47)

0.304‡

 Previous IS

8 (25.81)

18 (14.17)

0.117‡

 Previous ICH

1 (3.23)

4 (3.15)

0.983‡

 Previous TIA

0 (0)

4 (3.15)

0.716‡

Stroke in dominant hemisphere, n (%)

21 (67.74)

58 (45.67)

0.028‡

TOAST classification, n (%)

  

0.572‡

 Large-artery atherosclerosis

5 (16.13)

32 (25.20)

 

 Cardio-embolism

23 (74.19)

77 (60.63)

 

 Other determined etiology

1 (3.23)

7 (5.51)

 

 Undetermined etiology

2 (6.45)

11 (8.66)

 
  1. Abbreviations: PSM Propensity score matching, ST Standard therapy; SBP Systolic blood pressure, DBP Diastolic blood pressure, NIHSS National Institutes of Health Stroke Scale, GCS Glasgow Coma Scale, TIA Transit ischemic attack, IS Ischemic stroke, ICH Intracerebral hemorrhage
  2. *Student t test. † Mann–Whitney U test. ‡ χ2 test