The protective impact of education on brain structure and function in Alzheimer’s disease

BMC Neurology

Table 2 Results of voxel-based regression analyses between neuroimaging parameters and years of education

Region	Number of voxels	t-score	MNI coordinates
Region	Number of voxels	t-score	x	y	z
Negative correlations between years of education and GMV
dorsal anterior cingulate cortex	291	−5.25	0	20	33
Negative correlations between years of education and ReHo
left anterior part of inferior temporal cortex	65	−6	−57	− 12	−33
left posterior part of inferior temporal cortex	59	−4.69	−51	−30	−21
Negative correlations between years of education and left aITC rsFC
right angular gyrus	32	−4.79	45	−66	42
left mid frontal cortex	27	−5.57	−39	15	57
right superior frontal cortex	16	−4.95	24	27	54

Structural MR (GMV): Adjusted for age, sex, MMSE, and TIV
Resting-state fMRI (ReHo and rsFC): Adjusted for age, sex, MMSE, and head motion parameters
Coordinates (x,y,z) are given in MNI standard space. All regions listed are statistically significant at p<0.05 level (FDR corrected)
Abbreviations: GMV gray matter volume; ReHo Regional Homogeneity; rsFC resting-state functional connectivity; MNI Montreal Neurological Institute; aITC anterior part of inferior temporal cortex; MMSE Mini-Mental State Examination; TIV total intracranial volume

ISSN: 1471-2377