The protective impact of education on brain structure and function in Alzheimer’s disease

BMC Neurology

Table 4 Correlations between ROI-based neuroimaging variables and clinical cognitive function scores in AD group

Cognitive system	Episodic memory		Semantic memory		Working memory
Cognitive system	r	p	r	p	r	p
^aGMV of dACC	0.334	0.015*	0.453	0.001**	0.205	0.141
^bReHo of left aITC	0.172	0.217	0.049	0.728	0.021	0.884
^bReHo of left pITC	0.391	0.004**	0.2	0.151	0.102	0.466
Left aITC rsFC^b
right angular gyrus	0.312	0.023*	0.082	0.562	0.089	0.525
Left middle frontal cortex	0.338	0.013*	0.277	0.045*	0.084	0.552
right superior frontal cortex	0.108	0.44	−0.035	0.805	−0.128	0.36

The relationship between neuroimaging variables and clinical cognitive function scores were assessed by using Pearson correlation analysis
^aAdjusted for age, sex, education, and TIV
^bAdjusted for age, sex, education, and head motion parameters
P< 0.05*, P< 0.01**, P< 0.001***
Abbreviations: AD Alzheimer’s disease; GMV gray matter volume; ReHo Regional Homogeneity; rsFC resting-state functional connectivity; dACC dorsal anterior cingulate cortex; aITC anterior part of inferior temporal cortex; pITC posterior part of inferior temporal cortex; TIV total intracranial volume; ROI region of interest

ISSN: 1471-2377