Fig. 2

Regional quantification of longitudinal changes in cortical volume. A: 3D renderings show areas of cortical volume increases (red to yellow) and decreases (blue to cyan) as percent volume change per month between consecutive scans based on a vertex-wide analysis. Changes between consecutive scans were mapped to a temporal average and smoothed at FWHM = 15 mm. B: Net volume change across a 14-month period. (C): Bar graphs show average percentage change per month in lobar volume between consecutive scans. Asterisks highlight changes that are significantly different from zero (* p ≤ 0.05, ** p ≤ 0.01 and *** p < =0.001)