The Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo): rationale, aims, and study design

Table 15 Sample size justification for sub-cohorts

Sub-cohort	Proposed sample size	Effect size for continuous variable (OR)	Effect size for binary variable (OR)	Power (1 – Beta)
RIS	n = 100	1.8	3.7	0.80
RIS	n = 100	2.0	4.8	0.90
RIS	n = 150	1.6	2.8	0.80
RIS	n = 150	1.8	3.4	0.90
RRMS	n = 200	0.6	0.3	0.80
RRMS	n = 200	0.6	0.4	0.90
PPMS	n = 100	0.5	0.2	0.80
PPMS	n = 100	0.5	0.2	0.90

OR Odds Ratio, RIS Radiologically Isolated Syndrome, RRMS Relapsing Remitting Multiple Sclerosis, PPMS Primary Progressive Multiple Sclerosis

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