From: The Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo): rationale, aims, and study design
PPMS sub-cohort (n = 100)
Inclusion criteria
 Age 18–60
 EDSS [6] ≤ 6.5
 PPMS diagnosis [8] with symptom onset ≤10 years
Exclusion criteria
 HIV positive
 Previous or current treatment with chemotherapy for malignancy