Table 2 Clinical data of AE cases with multiple auto-antibodies
From: Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
N. | Sex, age | AE auto-Abs | Other Abs | Clinical manifestations | Brain MRI | tumor | prognosis | ||
|---|---|---|---|---|---|---|---|---|---|
serum | CSF | serum | CSF | ||||||
1 | M,62 | GABABR | GABABR | Hu | – | Memory loss, somnolence, conculsion, cough, hoarseness | Normal | Lung cancer | Improve |
2 | M,61 | GABABR | GABABR | Hu | – | Epilepsy, somnolence, memory loss | Normal | Lung cancer | Improve |
3 | M,59 | GABABR | GABABR | Hu | Hu | Epilepsy, psychosis | Lesions of bilateral hippocampus | Lung cancer | Improve |
4 | M,58 | GABABR | GABABR | Hu | Hu | Psychosis, memory loss, numbness of limbs | Lesions of bilateral hippocampus | Lung cancer | Improve |
5 | M,61 | GABABR | GABABR NMDAR | Hu | – | Epilepsy, memory loss, coma | ND | Lung cancer | Improve |
6 | F,19 | – | NMDAR | AQP4 | AQP4 | Psychosis, memory loss, blepharoptosis | Lesions of bilateral basal ganglia, brainstem | No | Improve |
7 | F,40 | LGI1 CASPR2 | LGI1 | – | – | Myalgia, fasciculation, epilepsy, insomnia | Normal | No | Improve |
8 | F,56 | LGI1 | LGI1 | Yo | Yo | Memory loss, conculsion, somnolence, polyphagia | Normal | No | Improve |
9 | F,50 | AMPAR | AMPAR | CV2 | CV2 | Memory loss, psychosis | Normal | Thymoma | Improve |
10 | F,51 | AMPAR | AMPAR | Hu | – | Psychosis, dysphagia, dysdipsia | Lesions of bilateral cortex | Mediastinal occupying | Dead |
11 | M,44 | ND | GABABR NMDAR | – | – | Limbic encephalitis | Not mentioned | No | Complete improve |
12 | F,63 | – | GABABR | GAD65 | Status epilepticus | Not mentioned | No | Dead | |
13 | M,60 | GABABR | GABABR | SOX1* | Limbic encephalitis | Not mentioned | SCLC | Partial recovery | |
14 | M,62 | GABABR | GABABR | Ri* | Limbic encephalitis | Not mentioned | SCLC | – | |
15 | F,68 | GABABR | GABABR | SOX1* | Limbic encephalitis | Not mentioned | SCLC | Partial recovery | |
16 | M,74 | GABABR | ND | SOX1 | ND | Limbic encephalitis | Not mentioned | SCLC | Dead |
17 | M,77 | GABABR | GABABR | Amphiphysin* | Limbic encephalitis | Not mentioned | SCLC | Unresponsive | |
18 | F,57 | LGI1 NMDAR | – | – | – | Faciobrachial dystonic seizure, hyponatremia, mental disorder | – | No | Improve |
19 | M,66 | GABABR* | GAD* | Seizures, confusion | Normal | SCLC | Not available | ||
20 | M,47 | GABABR* | SOX1*VGKC | Seizures, behavior change, memory impairment | Bilateral temporal lesions | SCLC | Partial recovery | ||
21 | M,70 | GABABR* | GAD* SOX1 | Seizures, memory impairment, confusion | Normal | SCLC | Unresponsive, dead | ||
22 | M,58 | GABABR* | Hu* | Seizures, memory impairment | Bilateral temporal lesions | SCLC | Unresponsive, dead | ||
23 | M,61 | GABABR* | BRSK2* | Memory impairment | Bilateral temporal lesions | SCLC | Unresponsive | ||
24 | F,57 | GABABR* | GAD* | Subacute cerebellar ataxia | Normal | Carcinoid of thymus | Complete recovery | ||
25 | F,30 | NMDAR GABABR | NMDAR | – | – | Epilepsy, psychosis, insomnia | Normal | No | Improve |
26 | F,43 | LGI1 CASPR2 | CASPR2 | – | – | Seizures, weight loss, calculation/ memory/speech disorder | Bilateral hippocampus/ occipital/parietal lesions | No | Improve |
27 | F,67 | LGI1 | Hu | Memory loss, motor aphasia | Left frontal/temporal/ parietal/occipital lobe | No | Improve | ||
28 | F,57 | NMDAR LGI1 | Seizures, facio-brachial dystonic seizures, somnolence | Demyelination of white matter | Probable lung cancer, thyroid nodule 4th | Improve | |||
29 | F,84 | GABABR | Hu | Seizures, cognitive impairment, confusion, psychosis | Left hippocampus and temporal lobe | Probable lung cancer | Dead | ||
30 | M,55 | NMDAR | Ma2 | Sensory aphasia, memory loss | Left temporal/occipital lobe and hippocampus | No | Improve | ||
31 | F,60 | GABABR | amphiphsin | Seizures, cognitive impairment, memory loss | Bilateral hippocampus, right temporal lobe | SCLC | Dead | ||
32 | M,67 | LGI1 | LGI1 NMDAR | Seizures, phychosis, memory loss, hand groping, hyponatremia | Unable to cooperate | No | Imptove | ||
33 | F,43 | NMDAR | Yo | Phychosis, seizures, memory loss | Bilateral hippocampus and temporal lobe | Myoma of uterus | Improve | ||
34 | F,82 | GABABR | GABABR | amphiphsin | amphiphsin | Memory loss, psychosis, disorientation | Left temporal lobe and hippocampus | Breast cancer | Unchanged |
35 | F,62 | SOX1 Titin | SOX1 | Polyneuropathy, subacute cerebellar degeneration | – | Cholangiocarcinoma | Dead | ||
36 | M,72 | GABABR | GABABR | Amphiphsin,Hu,GAD65 | Amphiphsin,Hu,GAD65 | Subacute sensory neuropathy, seizures, psychosis | – | Probable gastric cancer | Dead |
37 | M,62 | LGI1 | LGI1 | Yo | Yo | Memory loss, seizures, dizziness | Bilateral hippocampus | – | Improve |
38 | M,70 | LGI1 CASPR2 | Weekness of limbs, cognitive impairment, barylalia | – | Probable carcinoid of thymus | Improve | |||
39 | M.62 | Hu, Ri | Hu, Ri | Polyneuropathy | – | SCLC | Dead | ||
40 | M,58 | IgLON5 GABABR | IgLON5 | Dysarthria, gait instability, apraxia, hallucination,sleep disorder | Normal | No | Improve | ||