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Table 1 Clinical Characteristics at Baseline (n = 623) for patients with and without CSVD

From: Association between small dense low-density lipoprotein cholesterol and neuroimaging markers of cerebral small vessel disease in middle-aged and elderly Chinese populations

Variables

with CSVD(n = 487)

without CSVD n = 136)

P value

Age, y, mean ± SD

65.13 ± 9.98

60.38 ± 9.31

0.000

Male, n (%)

260(53.39)

58(42.65)

0.027

BMI, kg/m2, mean ± SD

26.82 ± 31.69

24.15 ± 3.08

0.309

Pulse pressure, mmHg, mean ± SD

51.67 ± 20.75

45.70 ± 21.47

0.004

Hypertension, n (%)

311(64.79)

53(39.55)

0.000

Diabetes, n (%)

109(22.71)

17(12.69)

0.011

Coronary artery disease, n (%)

38(7.92)

8(5.97)

0.449

Atrial fibrillation, n (%)

3(0.63)

0(0.00)

0.359

Previous cerebral hemorrhage, n (%)

15(3.13)

1(0.75)

0.126

Previous ischemic stroke, n (%)

179(37.29)

24(17.91)

0.000

Current smokers, n (%)

77(16.04)

20(14.93)

0.754

Current alcohol user, n (%)

65(13.54)

12(8.96)

0.156

CRP(mg/L), mean ± SD

4.06 ± 22.07

4.01 ± 17.03

0.981

D-dimer levels, mg/L, mean ± SD

0.55 ± 1.98

0.38 ± 0.42

0.369

FPG, mmol/L, mean ± SD

5.81 ± 2.09

5.34 ± 1.44

0.018

HbA1C, %, mean ± SD

5.99 ± 1.26

5.59 ± 0.88

0.002

creatinine, μmol /L, mean ± SD

64.95 ± 20.57

60.07 ± 14.28

0.011

Uric acid, μmol /L, mean ± SD

311.94 ± 85.93

294.61 ± 80.56

0.040

Lp(a), mg/L, mean ± SD

243.57 ± 230.55

272.18 ± 274.72

0.098

Total cholesterol, mean ± SD

4.40 ± 1.14

4.24 ± 1.17

0.136

Triglyceride, mean ± SD

1.98 ± 1.67

2.31 ± 1.96

0.062

LDL-C, mmol/L, mean ± SD

2.59 ± 0.84

2.39 ± 0.84

0.018

LDL-C1, mg/dl, mean ± SD

24.30 ± 13.48

30.14 ± 13.92

0.000

LDL-C2, mg/dl, mean ± SD

23.73 ± 10.35

23.04 ± 11.19

0.498

LDL-C3, mg/dl, mean ± SD

14.02 ± 8.11

8.40 ± 6.50

0.000

LDL-C4, mg/dl, mean ± SD

7.55 ± 6.99

2.69 ± 4.05

0.000

LDL-C5, mg/dl, mean ± SD

2.94 ± 4.82

0.56 ± 1.73

0.000

LDL-C6, mg/dl, mean ± SD

0.45 ± 1.57

0.08 ± 0.39

0.006

LDL-C7, mg/dl, mean ± SD

0.10 ± 0.57

0.06 ± 0.34

0.440

HDL-C, mmol/L, mean ± SD

1.12 ± 0.28

3.25 ± 16.12

0.005

Statin therapy, n (%)

242(50.42)

60(44.78)

0.248

Lipoprotein-associated phospholipase A2, ng/mL, mean ± SD

137.26 ± 23.83

140.26 ± 16.81

0.027

  1. Continuous variables are shown as the mean ± standard deviation (SD), categorical variables are shown as numbers combined with percentage (%). Pulse pressure means the difference between the systolic and diastolic pressures
  2. BMI Body mass index, CRP C-reactive protein, FPG fasting plasma glucose, HbA1C glycated hemoglobin, LDL-C indicates low-density lipoprotein cholesterol; Lp(a), lipoprotein(a)
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BMC Neurology

ISSN: 1471-2377

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