Table 1 Patient characteristics stratified by study inclusion

Age, years

59.9 (14.0)

55.1 (15.1)

<0.001

NA

Male

292 (67.0)

428 (63.9)

0.292

1.147 (0.889-1.479)

GCS

14 (9-15)

12 (6-14)

<0.001

NA

NIHSS

9 (3-14)

11 (4-27)

<0.001

NA

BP on admission, mmHg

NA

    Systolic BP

166.2 (26.9)

162.7 (32.8)

0.053

    Diastolic BP

95.8 (16.8)

97.0 (22.4)

0.296

 Hypertension

275 (63.1)

395 (59.0)

0.171

1.189 (0.928-1.524)

 Diabetes mellitus

40 (9.2)

38 (5.7)

0.026

1.680 (1.059-2.665)

 Dyslipidemia

120 (27.5)

177 (26.4)

0.685

1.058 (0.806-1.388)

 Heart disease

28 (6.4)

28(4.2)

0.096

1.574 (0.919-2.696)

Stroke history

44 (10.1)

52 (7.8)

0.179

1.334 (0.876-2.032)

Smoking

124 (28.4)

188 (28.1)

0.891

1.019 (0.780-1.332)

Alcohol consumption

125 (28.7)

172 (25.7)

0.272

1.164 (0.888-1.525)

HBV infection

302/436 (69.3)

451/629 (71.7)

0.391

0.889 (0.681-1.162)

 Antiplatelet drugs

12 (2.8)

5 (0.7)

0.008

3.764 (1.317-10.760)

 Anticoagulants

0 (0)

7 (1.0)

0.047

NA

ICH volume, ml

15.5 (7.6-33.5)

28.3 (10.1-49.8)

<0.001

NA

Location of bleed

<0.001

NA

 Deep location

287 (65.8)

319 (47.6)

 Lobar location

95 (21.8)

213 (31.8)

 Infratentorial location

54 (12.4)

138 (20.6)

IVH

124 (28.4)

231 (34.5)

0.036

0.755 (0.581-0.982)

Time from ICH onset to baseline scan, h

6.5 (4.0-12.5)

9.5 (5.0-25.0)

<0.001

NA

Laboratory findings

NA

 Platelet count, × 10⁹/L

158 (121-201)

164 (123-213)

0.141

 International normalized ratio

1.0 (0.9-1.0)

1.0 (0.9-1.1)

0.002

 Prothrombin time, sec

11.4 (10.9-12.0)

11.6 (11.0-12.3)

0.019

 APTT, sec

26.5 (24.3-29.3)

26.6 (24.0-29.4)

0.871

 Aspartate transaminase, IU/L

24 (20-31)

24 (19-31)

0.391

 Alanine transaminase, IU/L

21 (15-30)

20 (14-29)

0.511

 Albumin, g/dL

43.4 (41.2-45.8)

43.0 (40.2-45.6)

0.026