Skip to main content

Table 2 Characteristics of ICH patients within 24 h of ICH symptom onset (n = 436), stratified by HE

From: Liver fibrosis indices associated with substantial hematoma expansion in Chinese patients with primary intracerebral hemorrhage

Characteristic With HE
(n = 115)
Without HE
(n = 321)
p Value OR (95% CI)
Age, years 63.0 (14.5) 58.8 (13.7) 0.007 NA
Male 86 (74.8) 206 (64.2) 0.038 1.656 (1.026-2.672)
GCS 13 (9-15) 14 (9-15) 0.766 NA
NIHSS 9 (3-14) 8 (3-14) 0.773 NA
BP on admission, mmHg     NA
 Systolic BP 165.4 (27.5) 166.6 (26.8) 0.680  
 Diastolic BP 94.5 (18.1) 96.3 (16.4) 0.323  
Comorbidities
 Hypertension 76 (66.1) 199 (62.0) 0.435 1.195 (0.764-1.868)
 Diabetes mellitus 13 (11.3) 27 (8.4) 0.356 1.388 (0.690-2.792)
 Dyslipidemia 27 (23.5) 93 (29.0) 0.258 0.752 (0.459-1.233)
 Heart disease 8 (7.0) 20 (6.2) 0.785 1.125 (0.481-2.630)
Stroke history 13 (11.3) 31 (9.7) 0.615 1.192 (0.601-2.367)
Smoking 39 (33.9) 85 (26.5) 0.129 1.425 (0.900-2.254)
Alcohol consumption 35 (30.4) 90 (28.0) 0.626 1.123 (0.705-1.789)
HBV infection 80 (69.6) 222 (69.2) 0.935 1.019 (0.642-1.619)
Antiplatelet drugs 4 (3.5) 8 (2.5) 0.579 1.410 (0.416-4.774)
 ICH volume, ml     NA
 At admission 24.3 (8.3-45.4) 13.0 (7.6-30.5) 0.005  
 At follow-up 33.8 (16.5-56.2) 13.2 (6.7-30.0) <0.001  
Location of bleed    0.001 NA
 Deep location 60 (52.2) 227 (70.7)  
 Lobar location 37 (32.2) 58 (18.1)  
 Infratentorial location 18 (15.7) 36 (11.2)  
IVH 29 (25.2) 95 (29.6) 0.372 0.902 (0.494-1.302)
Symptom onset to first CT, h 6.0 (3.5-10.5) 7.0 (4.0-13.0) 0.083 NA
Time between the first and second CT, h 22.0 (4.0-32.0) 23.0 (7.0-38.0) 0.340 NA
Laboratory findings     NA
 Platelet count, ×109/L 140 (112-202) 160 (124-200) 0.038  
 International normalized ratio 1.0 (0.9-1.0) 1.0 (0.9-1.0) 0.887  
 Prothrombin time, sec 11.4 (10.8-12.1) 11.4 (10.9-12.0) 0.788  
 APTT, sec 26.5 (24.3-29.3) 26.5 (24.3-29.3) 0.844  
 Aspartate transaminase, IU/L 25 (20-32) 24 (20-31) 0.652  
 Alanine transaminase, IU/L 20 (15-28) 21 (15-32) 0.518  
 Albumin, g/dL 43.3 (41.2-46.1) 43.4 (41.1-43.4) 0.835  
Liver fibrosis index     NA
 APRI 0.4 (0.3-0.7) 0.4 (0.3-0.6) 0.245  
 AARPRI 1.3 (0.8-1.8) 1.1 (0.8-1.6) 0.069  
 FIB 4 2.4 (1.6-3.9) 2.1 (1.3-3.0) 0.016  
 mFIB 4 5.2 (3.4-8.5) 4.4 (2.6-7.1) 0.015  
 FibroQ 5.2 (3.4-8.1) 4.3 (2.6-7.1) 0.024  
 Forns index 6.6 (5.2-7.9) 6.2 (4.9-7.3) 0.017  
  1. Values are n (%), mean (SD) or median (interquartile range)
  2. Abbreviations: APRI AST to platelet ratio index, AARPRI AAR/platelet ratio index, where AAR is aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, FIB-4 fibrosis-4, mFIB-4 modified fibrosis-4, FibroQ fibrosis quotient, GCS Glasgow Coma Scale, NIHSS National Institutes of Health Stroke Scale, BP blood pressure, HBV hepatitis B virus, CT computed tomography, HE hematoma expansion, ICH intracerebral hemorrhage, IVH intraventricular hemorrhage, APTT activated partial thromboplastin time