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Table 3 Association between WBC counts within normal range (4 ~ 10*10^9/L) and the risk of fatal stroke in the GBCS, 2003–2017 (n = 24,082)

From: Higher total white blood cell and neutrophil counts are associated with an increased risk of fatal stroke occurrence: the Guangzhou biobank cohort study

 

Quartiles of WBC (*10^9/L), n = 24,082

P value trend

Quartiles of NEUT (*10^9/L), n = 23,968

P value trend

1st (< 5.3)

2nd 5.3–6.1)

3rd (6.2–7.2)

4th(> 7.2)

1st(< 3.0)

2nd (3.0–3.6)

3rd (3.7–4.4)

4th (> 4.5)

All stroke

 Person years

64,170

74,055

75,331

64,985

 

61,162

76,172

71,150

67,682

 

 per 10^5 person-years

99.7

114.8

160.6

212.4

 

91.6

116.8

142.0

236.4

 

 No. of deaths

64

85

121

138

 

56

89

101

160

 

 Model 2 (HR; 95% CI)

Ref.

1.01 (0.72–1.40)

1.33 (0.97–1.82)

1.56 (1.13–2.14)b

0.001

Ref.

1.05 (0.75–1.48)

1.17 (0.84–1.64)

1.64 (1.19–2.26)b

< 0.001

 P value

 

0.97

0.08

0.007

  

0.76

0.35

0.003

 

 Model 3 (HR; 95% CI)

Ref.

1.03 (0.66–1.60)

1.38 (0.90–2.10)

1.57 (1.02–2.42)a

0.012

Ref.

0.97 (0.61–1.54)

1.35 (0.87–2.09)

1.55 (1.00–2.41)a

0.009

 P value

 

0.91

0.14

0.04

  

0.88

0.19

0.05

 

Ischaemic stroke

 Person years

63,896

73,639

74,829

64,419

 

61,926

75,789

70,634

67,073

 

 per 10^5 person-years

53.2

48.9

78.8

97.8

 

45.2

55.4

60.9

116.3

 

 No. of deaths

34

36

59

63

 

28

42

43

78

 

 Model 2 (HR; 95% CI)

Ref.

0.81 (0.50–1.30)

1.21 (0.78–1.87)

1.29 (0.82–2.03)

0.08

Ref.

0.99 (0.61–1.60)

0.99 (0.61–1.60)

1.53 (0.97–2.42)

0.03

 P value

 

0.38

0.39

0.27

  

0.96

0.96

0.07

 

 Model 3 (HR; 95% CI)

Ref.

0.92 (0.48–1.80)

1.48 (0.80–2.73)

1.77 (0.94–3.30)

0.02

Ref.

1.37 (0.67–2.82)

1.53 (0.75–3.13)

2.47 (1.24–4.93)b

0.004

 P value

 

0.81

0.21

0.08

  

0.39

0.24

0.01

 

Haemorrhagic stroke

 Person years

63,762

73,572

74,521

64,174

 

61,849

75,628

70,486

66,702

 

 per 10^5 person-years

29.8

39.4

51.0

67.0

 

35.6

35.7

41.1

75.0

 

 No. of deaths

19

29

38

43

 

22

27

29

50

 

 Model 2 (HR; 95% CI)

Ref.

1.23 (0.69–2.21)

1.56 (0.88–2.74)

1.91 (1.07–3.40)a

0.02

Ref.

0.87 (0.49–1.53)

0.94 (0.53–1.65)

1.51 (0.89–2.57)

0.06

 P value

 

0.49

0.13

0.03

  

0.62

0.83

0.13

 

 Model 3 (HR; 95% CI)

Ref.

1.16 (0.56–2.41)

1.22 (0.59–2.53)

0.96 (0.43–2.14)

0.91

Ref.

0.61 (0.29–1.27)

0.93 (0.48–1.82)

0.60 (0.28–1.27)

0.40

 P value

 

0.69

0.59

0.92

  

0.18

0.83

0.18

 
  1. Ref: reference; C P < 0.001, b P < 0.01, aP < 0.05; model 2: a multivariate model adjusted for sex, age, education, occupation, diabetes, hypertension, dyslipidaemia, smoking, alcohol consumption, physical activity, body mass index, self-rated health, cancer, genitourinary disease (including nephropathy, prostatic disease, and gynaecologic diseases), chest disease (including chronic obstructive pulmonary disease, chronic bronchitis, emphysema, asthma, tuberculosis, and pneumonia) and platelet count; model 3: Model 2 + adjustment for CRP. WBC count analysis was conducted in 10,041 participants. NEUT count analysis was conducted in 9946 participants without stroke or a CVD history, and a NEUT count in the top 1% or bottom 1% was excluded.
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BMC Neurology

ISSN: 1471-2377

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