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Table 5 Association between WBC count changes and the risk of fatal stroke in the GBCS, 2003–2012 (n = 16,296)

From: Higher total white blood cell and neutrophil counts are associated with an increased risk of fatal stroke occurrence: the Guangzhou biobank cohort study

 

All stroke

Ischaemic stroke

Haemorrhagic stroke

Loss

(<−10%)

Stable

(−10–10%)

Gain

(> 10%)

Loss

(<−10%)

Stable

(−10–10%)

Gain

(> 10%)

Loss

(<−10%)

Stable

(− 10–10%)

Gain

(> 10%)

WBC change

 Person years

33,933

57,901

36,426

33,835

57,710

36,216

33,757

57,602

36,154

 per 10^5 person-years

135.6

134.7

183.9

73.9

71.0

77.3

41.5

41.7

63.6

 No. of deaths

46

78

67

25

41

28

14

24

23

 Model 1 (HR; 95% CI)

1.01 (0.70–1.45)

Ref.

1.36 (0.98–1.89)

1.05 (0.64–1.73)

Ref.

1.08 (0.67–1.74)

0.99 (0.51–1.91)

Ref.

1.54 (0.87–2.73)

 P value

0.96

 

0.07

0.85

 

0.76

0.97

 

0.14

 Model 2 (HR; 95% CI)

0.93 (0.64–1.34)

Ref.

1.35 (0.97–1.88)

0.92 (0.56–1.52)

Ref.

1.06 (0.66–1.72)

0.94 (0.48–1.82)

Ref.

1.48 (0.83–2.63)

 P value

0.70

 

0.08

0.75

 

0.80

0.85

 

0.18

NEUT change

 Person years

43,239

43,221

41,800

43,133

43,057

41,570

43,040

42,974

41,498

 per 10^5 person-years

115.6

150.4

181.8

64.9

76.6

79.4

32.5

46.5

65.1

 No. of deaths

50

65

76

28

33

33

14

20

27

 Model 1 (HR; 95% CI)

0.76 (0.53–1.10)

Ref.

1.21 (0.87–1.69)

0.85 (0.51–1.40)

Ref.

1.04 (0.64–1.68)

0.69 (0.35–1.36)

Ref.

1.41 (0.79–2.52)

 P value

0.15

 

0.25

0.52

 

0.89

0.28

 

0.24

 Model 2 (HR; 95% CI)

0.72 (0.49–1.04)

Ref.

1.18 (0.85–1.65)

0.75 (0.45–1.24)

Ref.

1.00 (0.61–1.62)

0.69 (0.35–1.37)

Ref.

1.38 (0.77–2.46)

 P value

0.08

 

0.33

0.26

 

0.99

0.29

 

0.28

 

Loss (<−25%)

Stable

(−25–25%)

Gain

(> 25%)

Loss

(<−25%)

Stable

(−25–25%)

Gain

(> 25%)

Loss

(<−25%)

Stable

(−25–25%)

Gain

(> 25%)

WBC change

 Person years

7992

107,611

12,657

7972

107,225

12,565

7936

107,055

12,522

 per 10^5 person-years

162.7

139.4

221.2

112.9

67.1

103.5

46.6

46.6

63.9

 No. of deaths

13

150

28

9

72

13

3

50

8

 Model 1 (HR; 95% CI)

1.18 (0.67–2.08)

Ref.

1.58 (1.06–1.37)a

1.72 (0.86–3.43)

Ref.

1.53 (0.85–2.76)

0.80 (0.25–2.57)

Ref.

1.38 (0.65–2.91)

 P value

0.57

 

0.03

0.13

 

0.16

0.71

 

0.40

 Model 2 (HR; 95% CI)

1.05 (0.59–1.85)

Ref.

1.60 (1.07–2.40)a

1.48 (0.74–2.98)

Ref.

1.58 (0.87–2.87)

0.77 (0.24–2.46)

Ref.

1.37 (0.65–2.92)

 P value

0.86

 

0.02

0.27

 

0.13

0.65

 

0.41

NEUT change

 Person years

17,019

89,795

21,445

16,985

89,459

21,317

16,933

89,332

21,248

 per 10^5 person-years

129.3

140.3

200.5

94.2

63.7

98.5

29.5

48.1

61.2

 No. of deaths

22

126

43

16

57

21

5

43

13

 Model 1 (HR; 95% CI)

0.92 (0.59–1.45)

Ref.

1.43 (1.02–2.03)a

1.49 (0.86–2.60)

Ref.

1.54 (0.94–2.55)

0.61 (0.24–1.53)

Ref.

1.29 (0.69–2.39)

 P value

0.72

 

0.04

0.16

 

0.09

0.29

 

0.43

 Model 2 (HR; 95% CI)

0.88 (0.56–1.38)

Ref.

1.45 (1.02–2.05)a

1.37 (0.79–2.40)

Ref.

1.59 (0.96–2.64)

0.61 (0.24–1.54)

Ref.

1.25 (0.67–2.34)

 P value

0.57

 

0.04

0.27

 

0.07

0.30

 

0.49

  1. Ref: reference; C P < 0.001, b P < 0.01, aP < 0.05; model 1: a crude hazard ratio model without adjustment for confounders; model 2: a multivariate model adjusted for sex, age, education, occupation, diabetes, hypertension, dyslipidaemia, smoking, alcohol consumption, physical activity, body mass index, self-rated health, cancer, genitourinary disease (including nephropathy, prostatic disease, and gynaecologic diseases), chest disease (including chronic obstructive pulmonary disease, chronic bronchitis, emphysema, asthma, tuberculosis, and pneumonia) and platelet count
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