Table 1 Baseline and three-month characteristics according to the first event after three-month follow-up
All N = 354 | New IS N = 16 | Death N = 251 | No event N = 313 | P-value | |
|---|---|---|---|---|---|
Age2,3, mean years (SD) | 73 (11) | 73 (10) | 82 (9) | 73 (11) | < 0.001 |
Male4 sex, n (%) | 201 (57) | 11 (69) | 16 (64) | 174 (56) | 0.439 |
Observation time3, mean years (SD) | 2.5 (6) | 1.5 (1.0) | 1.6 (0.7) | 2.6 (0.5) | < 0.001 |
Baseline | |||||
TOAST4 subtype6, n (%) | 0.661 | ||||
Large artery | 30 (9) | 1 (6) | 0 | 29 (10) | |
Cardioembolic | 72 (21) | 5 (31) | 6 (24) | 61 (20) | |
Small vessel disease | 83 (24) | 4 (25) | 6 (7) | 73 (24) | |
Other determined | 10 (3) | 1 (6) | 0 | 9 (3) | |
Undetermined | 128 (43) | 5 (31) | 13 (52) | 128 (43) | |
Prior IS4, n (%) | 72 (20) | 7 (44) | 13 (52) | 52 (17) | < 0.001 |
Prior CHD4, n (%) | 61 (17) | 3 (19) | 10 (40) | 48 (13) | 0.007 |
Atrial fibrillation4, n (%) | 89 (25) | 6 (37) | 11 (44) | 72 (23) | 0.034 |
Hypertension4, n (%) | 202 (57) | 11 (69) | 19 (76) | 172 (60) | 0.077 |
Hypercholesterolemia4, n (%) | 178 (50) | 8 (50) | 16 (64) | 154 (46) | 0363 |
Diabetes mellitus4, n (%) | 60 (17.0) | 0 | 6 (24) | 54 (17) | 0.124 |
Three-months | |||||
NIHSS5 median (IQR) | 0 (1) | 1 (1) | 0.5(3) | 0 (1) | 0.122 |
BI5 median (IQR) | 100 (0) | 100 (0) | 95 (17) | 100 (0) | 0.017 |
mRS5 median (IQR) | 1 (1) | 2 (1) | 3 (2) | 1 (1) | < 0.001 |
Waist2, 3, mean cm (SD) | 95 (13) | 89 (15) | 98 (15) | 95 (13) | 0.137 |
Current smoking2, 4, n (%) | 31 (9) | 1 (7) | 4 (17) | 26 (9) | 0.597 |
Laboratory measures2,5 | |||||
CRP, median (IQR), n = 267 | 1.6 (2.9) | 1.1 (5.3) | 3.0 (26.5) | 1.6 (2.9) | 0.053 |
IL-6, median (IQR), n = 334 | 4.6 (4.5) | 4.8 (4.1) | 6.1 (6.1) | 4.2 (4.2) | 0.038 |
Neopterin, median (IQR), n = 334 | 16 (10) | 17 (12) | 24 (17) | 16 (9) | < 0.001 |
PAr-index, median (IQR), n = 334 | 0.62 (0.46) | 0.57 (0.80) | 1.0 (0.8) | 0.60 (0.42) | 0.002 |
Kynurenic acid, n = 334 | 58 (30) | 56 (35) | 65 (52) | 59 (29) | 0.522 |