| |
Crude
|
Model 1
|
Model 2
|
---|
|
HR
|
CI
|
P
|
HR
|
CI
|
p
|
HR
|
CI
|
P
|
---|
Recurrent ischemic stroke, N = 16
|
|
CRP1)
|
0.90
|
(0.44, 1.83)
|
0.772
|
0.86
|
(0.41, 1.77)
|
0.674
|
0.92
|
(0.44, 1.90)
|
0.816
|
|
IL-6
|
1.11
|
(0.67, 1.86)
|
0.686
|
1.19
|
(0.52, 1.97)
|
0.578
|
1.10
|
(0.30, 2.02)
|
0.754
|
|
Neopterin
|
1.34
|
(0.85, 2.11)
|
0.209
|
1.45
|
(0.82, 2.57)
|
0.201
|
1.39
|
(0.80, 2.41)
|
0.244
|
|
PAr
|
1.16
|
(0.71, 1.90)
|
0.553
|
1.13
|
(0.61, 2.10)
|
0.692
|
1.24
|
(0.67, 2.31)
|
0.494
|
|
KA
|
0.91
|
(0.55, 1.50)
|
0.710
|
0.82
|
(0.41, 1.61)
|
0.563
|
0.89
|
(0.43, 1.86)
|
0.761
|
Death2, N = 28
|
|
CRP1)
|
1.81
|
(1.29, 2.53)
|
0.001
|
1.40
|
(1.01, 1.96)
|
0.046
|
1.41
|
(1.00, 1.99)
|
0.053
|
|
IL-6
|
1.74
|
(1.20, 2.51)
|
0.003
|
1.34
|
(0.87, 2.07)
|
0.181
|
1.36
|
(0.87, 2.12)
|
0.173
|
|
Neopterin
|
1.93
|
(1.43, 2.61)
|
< 0.001
|
1.44
|
(0.89, 2.33)
|
0.136
|
1.55
|
(0.91, 2.64)
|
0.104
|
|
PAr
|
1.69
|
(1.15, 2.49)
|
0.008
|
1.11
|
(0.68, 1.82)
|
0.666
|
1.13
|
(0.67, 1.90)
|
0.641
|
|
KA
|
1.12
|
(0.75, 1.66)
|
0.577
|
0.64
|
(0.38, 1.07)
|
0.088
|
0.69
|
(0.41, 1.14)
|
0.145
|
Stroke and death, N = 41
|
|
CRP1)
|
1.59
|
(1.16, 2.18)
|
0.004
|
1.27
|
(0.92, 1.74)
|
0.140
|
1.27
|
(0.93, 1.74)
|
0.135
|
|
IL-6
|
1.47
|
(1.08, 2.02)
|
0.016
|
1.23
|
(0.85, 1.77)
|
0.274
|
1.23
|
(0.85, 1.77)
|
0.275
|
|
Neopterin
|
1.79
|
(1.39, 2.31)
|
< 0.001
|
1.52
|
(1.06, 2.20)
|
0.023
|
1.55
|
(1.06, 2.27)
|
0.025
|
|
PAr
|
1.62
|
(1.19, 2.22)
|
0.002
|
1.28
|
(0.86, 1.90)
|
0.224
|
1.34
|
(0.89, 2.01)
|
0.162
|
|
KA
|
1.27
|
(0.58, 2.79)
|
0.555
|
0.55
|
(0.19, 1.54)
|
0.252
|
0.60
|
(0.21, 1.71)
|
0.339
|
- HR = hazard ratio. CI = confidence interval. CRP = C-reactive protein. IL-6 = Interleukin-6. PAr = PAr-index = pyridoxic acid ratio-index = 4-pyridoxic acid:(pyridoxal+pyridoxal-5`-phosphate). KA = kynurenic acid. Each biomarker was investigated individually
- Model 1: Age, sex, prior cerebrovascular disease, modified Rankin Scale at 3 months, creatinine
- Model 2: As in model 1 + TOAST-classification at baseline (TOAST = Trial of Org 10,172 in Acute Stroke Treatment)
- 1For CRP, N = 212, 8 and 13 for all, recurrent IS and death, respectively
- 2Includes both those with and without ischemic stroke recurrence prior to death