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Table 4 Adjusted Cox regression (Model 1) of the combined contributions of kynurenic acid and neopterin in stroke, mortality and the composite endpoint (stroke and death)

From: Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke

 

Stroke recurrence

Death

Stroke and death

 

HR

CI

p

HR

CI

p

HR

CI

p

KA

0.78

(0.39, 1.57)

0.492

0.57

(0.33, 0.97)

0.038

0.72

(0.46, 1.10)

0.131

Neopterin

1.48

(0.83, 1.57)

0.177

1.61

(1.02, 2.54)

0.040

1.59

(1.11, 2.27)

0.011

Age

0.98

(0.51, 2.61)

0.949

1.11

(0.60, 2.06)

0.746

1.09

(0.68, 1.76)

0.720

Sex

1.39

(0.73, 2.66)

0.314

1.61

(1.00, 2.62)

0.052

1.43

(0.97, 2.10)

0.071

Prior CeVD

1.37

(0.87, 2.17)

0.175

1.56

(1.10, 2.22)

0.012

1.44

(1.08, 1.91)

0.012

mRS

0.97

(0.46, 2.05)

0.945

3.25

(1.77, 5.96)

< 0.001

2.24

(1.40, 3.57)

0.001

Creatinine

1.31

(0.20, 3.38)

0.583

2.23

(1.12, 4.42)

0.022

1.65

(0.93, 2.92)

0.085

  1. The analyses includes KA, neopterin and Model 1: Age, sex, prior cerebrovascular disease, modified Rankin Scale at three months, creatinine
  2. HR = hazard ratio. CI = confidence interval. KA = kynurenic acid. CeVD = cerebrovascular disease. mRS = modified Rankin Scale