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Table 4 Clinical outcome variables

From: Feasibility of low-dose dexmedetomidine for prevention of postoperative delirium after intracranial operations: a pilot randomized controlled trial

 

Placebo (n = 30)

Dexmedetomidine (n = 30)

P

Use of sedatives during study-drug infusion, n (%)

1 (3.3)

3 (10.0)

0.601

Propofol

0 (0.0)

1 (3.3)

 

Midazolam

1 (3.3)

2 (6.7)

 

Use of opioids during study-drug infusion, n (%)

6 (20.0)

5 (16.7)

> 0.999

Remifentanil

1 (3.3)

1 (3.3)

 

Butorphanol

5 (16.7)

4 (13.3)

> 0.999

RASS at the end of study-drug infusion, median (IQR)

0 (0–0)

0 (0–0)

> 0.999

Subjective pain score on postoperative day one, median (IQR)

4 (0–6)

3 (2–4)

0.192

Subjective sleep score on postoperative day one, median (IQR)

5 (2–9)

2 (1–7)

0.142

Time to extubation,* median (IQR), hours

17 (16–19)

18 (15–19)

> 0.999

Non-delirium complications, n (%)

7 (23.3)

4 (13.3)

0.506

Length of stay in the ICU, median (IQR), hours

17 (15–19)

18 (16–19)

0.376

Length of stay in hospital after the operation, median (IQR), days

9 (8–12)

11 (8–15)

0.247

Mini-Cog at the end of follow-up, median (IQR)

5 (4–5)

5 (4–5)

0.507

  1. * Result in endotracheal intubated patients on the ICU admission
  2. ICU intensive care unit, IQR interquartile range