Table 2 Univariable Analyses of Predictors for Cognitive Decline and Depression Onset Profiles after ICH
From: Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage
Variable | Depression / Dementia Profiles after ICH | p | |||
|---|---|---|---|---|---|
Profile I Low Depression and Dementia Risk | Profile II Early Depression and Dementia | Profile III Late Depression and Dementia | Profile IV High Depression with Low Dementia Risk | ||
No. of individuals | 75 | 189 | 387 | 133 | – |
Pre-ICH Depression | 12 (13) | 37 (20) | 58 (15) | 28 (21) | 0.003 |
ICH Volume (median, IQR) | 18.1 (6.3–28.8) | 26.5 (9.6–33.2) | 20.2 (7.2–26.4) | 17.8 (6.4–27.5) | < 0.001 |
Intraventricular Hemorrhage | 19 (25) | 62 (33) | 89 (23) | 34 (26) | 0.035 |
Discharge mRS (median, IQR) | 4 (3–4) | 4 (4–5) | 4 (3–5) | 4 (3–5) | 0.075 |
CSVD MRI Score (median, IQR) | 2 (1–2) | 2 (1–3) | 3 (2–3) | 2 (1–3) | 0.041 |
CAA-related ICH | 33 (44) | 93 (49) | 219 (57) | 55 (41) | 0.002 |
APOE ε2 (≥ 1 copy) | 8 (11) | 30 (16) | 55 (14) | 17 (13) | 0.085 |
APOE ε4 (≥ 1 copy) | 13 (17) | 32 (17) | 97 (25) | 23 (17) | 0.012 |