Skip to main content

Table 2 Univariable Analyses of Predictors for Cognitive Decline and Depression Onset Profiles after ICH

From: Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage

Variable Depression / Dementia Profiles after ICH p
Profile I
Low Depression
and Dementia Risk
Profile II
Early Depression
and Dementia
Profile III
Late Depression
and Dementia
Profile IV
High Depression
with Low Dementia Risk
No. of individuals 75 189 387 133
Pre-ICH Depression 12 (13) 37 (20) 58 (15) 28 (21) 0.003
ICH Volume
(median, IQR)
18.1 (6.3–28.8) 26.5 (9.6–33.2) 20.2 (7.2–26.4) 17.8 (6.4–27.5) < 0.001
Intraventricular
Hemorrhage
19 (25) 62 (33) 89 (23) 34 (26) 0.035
Discharge mRS
(median, IQR)
4 (3–4) 4 (4–5) 4 (3–5) 4 (3–5) 0.075
CSVD MRI Score
(median, IQR)
2 (1–2) 2 (1–3) 3 (2–3) 2 (1–3) 0.041
CAA-related ICH 33 (44) 93 (49) 219 (57) 55 (41) 0.002
APOE ε2 (≥ 1 copy) 8 (11) 30 (16) 55 (14) 17 (13) 0.085
APOE ε4 (≥ 1 copy) 13 (17) 32 (17) 97 (25) 23 (17) 0.012
  1. P-values reported for univariable comparisons across patient subgroups defined by specific profiles in cognitive and mood symptoms after ICH. We report results for variables with p < 0.20 in univariable analyses
  2. Abbreviations: CAA Cerebral Amyloid Angiopathy, CSVD Cerebral Small Vessel Disease, ICH Intracerebral Hemorrhage, IQR Inter-quartile Range, mRS modified Rankin Scale