Table 3 Multivariable Analyses of Predictors for Cognitive Decline and Depression Onset Profiles after ICH

Pre-ICH Depression

Ref.

–

1.83 (1.16–2.86)

0.011

0.89 (0.71–1.11)

0.31

2.14 (1.25–3.64)

0.008

ICH Volume

(per 10 cc increase)

Ref.

–

1.38 (1.03–1.84)

0.041

1.52 (0.73–3.14)

0.28

0.75 (0.54–1.02)

0.098

Intraventricular

Hemorrhage

Ref.

–

1.78 (1.07–2.95)

0.031

0.68 (0.38–1.20)

0.20

1.28 (0.69–2.35)

0.45

Discharge mRS

(per 1 point increase)

Ref.

–

1.41 (1.09–1.82)

0.009

1.18 (0.94–1.47)

0.17

0.67 (0.44–1.01)

0.071

CSVD MRI Score

(per 1 point increase)

Ref.

–

1.11 (0.85–1.44)

0.44

1.28 (1.05–1.55)

0.021

0.71 (0.40–1.25)

0.25

CAA-related ICH

Ref.

–

1.29 (0.95–1.73)

0.11

1.84 (1.21–2.79)

0.007

1.36 (0.93–1.98)

0.13

APOE ε2

(≥ 1 copy)

Ref.

–

1.28 (0.99–1.64)

0.063

1.37 (0.92–2.02)

0.13

0.88 (0.40–1.91)

0.75

APOE ε4

(≥ 1 copy)

Ref.

–

1.12 (0.84–1.48)

0.45

1.57 (1.07–2.29)

0.028

0.79 (0.37–1.65)

0.55