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Table 3 Multivariable Analyses of Predictors for Cognitive Decline and Depression Onset Profiles after ICH

From: Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage

Predictor
Variables
Cognitive Decline and Depression Onset Profiles
Profile I
Low Depression
and Dementia Risk
Profile II
Early Depression
and Dementia
Profile III
Late Depression
and Dementia
Profile IV
High Depression
with Low Dementia Risk
RRR (95% CI) p RRR (95% CI) p RRR (95% CI) p RRR (95% CI) p
Pre-ICH Depression Ref. 1.83 (1.16–2.86) 0.011 0.89 (0.71–1.11) 0.31 2.14 (1.25–3.64) 0.008
ICH Volume
(per 10 cc increase)
Ref. 1.38 (1.03–1.84) 0.041 1.52 (0.73–3.14) 0.28 0.75 (0.54–1.02) 0.098
Intraventricular
Hemorrhage
Ref. 1.78 (1.07–2.95) 0.031 0.68 (0.38–1.20) 0.20 1.28 (0.69–2.35) 0.45
Discharge mRS
(per 1 point increase)
Ref. 1.41 (1.09–1.82) 0.009 1.18 (0.94–1.47) 0.17 0.67 (0.44–1.01) 0.071
CSVD MRI Score
(per 1 point increase)
Ref. 1.11 (0.85–1.44) 0.44 1.28 (1.05–1.55) 0.021 0.71 (0.40–1.25) 0.25
CAA-related ICH Ref. 1.29 (0.95–1.73) 0.11 1.84 (1.21–2.79) 0.007 1.36 (0.93–1.98) 0.13
APOE ε2
(≥ 1 copy)
Ref. 1.28 (0.99–1.64) 0.063 1.37 (0.92–2.02) 0.13 0.88 (0.40–1.91) 0.75
APOE ε4
(≥ 1 copy)
Ref. 1.12 (0.84–1.48) 0.45 1.57 (1.07–2.29) 0.028 0.79 (0.37–1.65) 0.55
  1. Results from multivariable logistic regression analyses of risk factors for participants’ assignment to specific profiles in cognitive and mood symptoms after ICH. Effect sizes (RRR) and p-values represent comparison for each group with the patient subset at low risk for both dementia and depression after ICH, which was selected as reference
  2. Abbreviations: 95% CI 95% Confidence Interval, CAA Cerebral Amyloid Angiopathy, CSVD Cerebral Small Vessel Disease, ICH Intracerebral Hemorrhage, IQR Inter-quartile Range, mRS modified Rankin Scale, RRR Relative Risk Ratio