An autopsied case report of spastic paraplegia with thin corpus callosum carrying a novel mutation in the SPG11 gene: widespread degeneration with eosinophilic inclusions

Table 1 Neuropathological findings

	Degeneration		p62-immunoreactive neuronal cytoplasmic inclusions
	Neuronal loss	Gliosis	Frequency
Cerebral cortex
Frontal cortex	+	++	+
Motor cortex	++	++	+
Temporal cortex	-	+	+
Parietal cortex	-	+	+
Visual cortex	+	+	+
Limbic areas
Amygdala	++	++	+
Hippocampus	+	+	-
Transentorhinal/entorhinal cortex	-	+	-
Anterior cingulate cortex	+	++	+
Insular cortex	+	++	-
Basal ganglia
Caudate nucleus	++	++	+
Putamen	++	++	+
Globus pallidus	-	+	-
Subthalamic nucleus	+	+	+++
Nucleus basalis of Meynert	-	+	++
Thalamus
Anterior nuclear group	++	+++	+
Dosal medial nuclear group	+++	+++	++
Ventral lateral nuclear group	+++	+++	++
Purvinar	+++	+++	+
Lateral geniculate body	+++	+++	+
Midbrain
Oculomotor nucleus	-	+	+++
Red nucleus	+	++	-
Substantia nigra pars compacta	+++	++	++
Substantia nigra pars reticulata	++	++	+
Pons
Trigeminal motor nucleus	+	++	+++
Facial nucleus	+++	+++	++
Pontine nucleus	-	+	+
Locus coeruleus	+++	+++	-
Medulla oblongata
Hypoglossal nucleus	+++	++	++
Dorsal vagal nucleus	++	++	-
Inferior olivary nucleus	+	+	+
Cerebellum
Purkinje cells in vermis	+++	+++	-
Purkinje cells in hemisphere	+	+	-
Cerebellar dentate nucleus	++	++	++
Spinal cord
Anterior horn	+++	+++	+
Intermediate lateral nucleus	+	++	+
Clarke's column	++++	+++	-
Onuf's nucleus	++++	+++	-
Peripheral tissue
Dorsal root ganglion	++	NA	+++

NA Not assessed
Neuronal loss was indicated as absent (-), mild (+), moderate (++), severe (+++), or totally lost (++++)
Gliosis was indicated as mild (+), moderate (++), or severe (+++)
The frequency of p62-immunoreactive neuronal cytoplasmic inclusions (NCI), evaluated at a 10× objective magnification, is indicated as follows: no NCI across the entire section (-), an average of 0–2 inclusions (+), an average of 3–9 inclusions (++), and an average of ≥10 inclusions (+++) per field

ISSN: 1471-2377