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Fig. 3 | BMC Neurology

Fig. 3

From: Leukoencephalopathy with brain calcifications and cysts (Labrune syndrome) case report: diagnosis and management of a rare neurological disease

Fig. 3

Histopathologic features of LCC. A-D) H&E-stained sections showing a spectrum of microangiopathic change, ranging from mild mural hyalinization (A) to severe sclerosis with mural deposition of fibrinoid material (B,C; inset: Martius scarlet blue stain) to complete obliteration (D). Perivascular hemosiderin-laden macrophages were a frequent finding (D, arrowheads), along with myelin pallor (E, LFB/PAS stain, arrowheads; asterisk marks vessel remnant) and axonal loss (F, neurofilament immunohistochemistry, arrowheads; asterisk marks vessel remnant). Gliosis was most intense in perivascular areas, with focal formation of Rosenthal fibres (G, arrowheads) and highlighted by GFAP immunohistochemistry (H, asterick). Small calcospherites were scattered randomly in the white matter (I). Scale bars: 100 µm

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