Skip to main content

Table 4 Comparison of normalized subcortical brain structure volumes in mm3 in AIS and PVI children at different bimanual motor outcome levels of the MACS scale

From: Ipsilesional volume loss of basal ganglia and thalamus is associated with poor hand function after ischemic perinatal stroke

Structure normalized [mm3]

AIS

n = 16

PVI

n = 18

MACS

I

n = 6

II

n = 3

III-IV

n = 7

p-value

I

n = 5

II

n = 8

III-IV

n = 5

p value

mean (95% CI) or median (IQR)*

mean (95% CI) or median (IQR)*

mean (95% CI) or median (IQR)*

mean (95% CI)

mean (95% CI)

mean (95% CI)

Thalamus, ipsilesional

9919

(8758–11,080)

9945

(7865–12,025)

5485

(2991–7980)

0.003 #$

10,649

(8721–12,577)

9162

(8578–9746)

6895

(4187–9603)

0.004 #$

Thalamus, contralesional

10,110

(9643–10,307)*

10,237

(10227–11,289)*

10,291

(9587–10,988)*

0.861 *

11,371

(10364–12,378)

10,544

(9830–11,258)

10,190

(9709–10,672)

0.062

Caudate nucleus, ipsilesional

5266

(4345–6186)

5872

(2560–9183)

4182

(2449–5915)

0.355

5416

(4205–6628)

4801

(4218–5383)

4067

(2769–5364)

0.082

Caudate nucleus, contralesional

5506

(4761–6252)

5987

(4539–7435)

6235

(5211–7258)

0.372

5664

(4678–6649)

5825

(5178–6472)

5787

(4954–6620)

0.931

Putamen, ipsilesional

6778

(5926–7629)

7242

(1967–12,518)

4314

(1469–7159)

0.248

7099

(5677–8522)

6984

(6344–7624)

6505

(5156–7855)

0.590

Putamen, contralesional

7171

(6486–7856)

8140

(5749–10,530)

8311

(7508–9114)

0.063

7007

(5952–8063)

7185

(6764–7605)

7476

(6569–8384)

0.550

Globus pallidus, ipsilesional

2324

(2097–2551)

2148

(974–3322)

1459

(723–2194)

0.122

2415

(2052–2778)

2236

(2107–2365)

1953

(1456–2451)

0.055

Globus pallidus, contralesional

2469

(2209–2730)

2606

(1657–3556)

2400

(2147–2653)

0.588

2575

(2145–3005)

2604

(2373–2834)

2403

(2082–2724)

0.478

Hippocampus, ipsilesional

4831

(4252–5410)

4911

(3044–6778)

3881

(2874–4888)

0.120

4680

(3787–5573)

4960

(4631–5288)

4619

(3518–5720)

0.604

Hippocampus, contralesional

5095

(4516–5673)

4828

(4233–5424)

5858

(5431–6286)

0.010

5140

(4560–5720)

5193

(4652–5734)

5306

(4573–6038)

0.901

Amygdala, ipsilesional

1647

(1312–1983)

1474

(1178–1770)

1203

(805–1602)

0.116

1567

(1229–1904)

1602

(1307–1898)

1402

(981–1824)

0.565

Amygdala, contralesional

1705

(1381–2030)

1679

(985–2374)

1371

(1025–1716)

0.196

1605

(1135–2074)

1531

(1264–1799)

1569

(1317–1821)

0.918

Nucleus accumbens, ipsilesional

632

(439–825)

584

(61–1108)

407

(245–568)

0.110

664

(451–877)

786

(675–897)

603

(243–963)

0.306

Nucleus accumbens, contralesional

630

(501–759)

703

(613–793)

500

(349–651)

0.093

572

(428–717)

655

(534–777)

601

(544–658)

0.458

  1. bold text = significant p-value after FDR correction (using level 0.05, the single comparison cutoff p-value being 0.0042 for the AIS and PVI groups);
  2. # = mean volume difference between subjects with MACS I and III-IV;
  3. $ = mean volume difference between subjects with MACS II and III-IV;
  4. * = absence of normal distribution (Kruskal-Wallis test used instead of ANOVA)
Back to article page

BMC Neurology

ISSN: 1471-2377

Contact us