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Table 4 APD Delphi criteria frequency distribution in APD and non-APD patients; N (%)

From: Criteria for identification of advanced Parkinson’s disease: the results of the Italian subgroup of OBSERVE-PD observational study

  APD (N = 60) Non-APD (N = 80)
Severity of Motor Fluctuations
 None 9 (15%) 71 (88.8%)
 Mild 28 (46.7%) 9 (11.2%)
 Moderate 18 (30%) 0
 Severe 5 (8.3%) 0
Number of OFF hours during waking day
 None 5 (8.3%) 62 (77.5%)
 < 2 h 37 (61.7%) 17 (21.3%)
 2–4 h 11 (18.3%) 1 (1.2%)
 > 4 h 7 (11.7%) 0
Severity of night sleep disturbances
 None 10 (16.7%) 48 (60%)
 Mild 27 (45%) 24 (30%)
 Moderate 19 (31.7%) 8 (10%)
 Severe 4 (6.6%) 0
Number of hours with troublesome dyskinesia
 None 14 (23.3%) 68 (85%)
 < 2 h 19 (31.7%) 11 (13.8%)
 2–3 h 16 (26.7%) 0
  > 3 h 11 (18.3%) 1 (1.2%)
Presence of non-motor fluctuations
 Yes 36 (60%) 6 (7.5%)
 No 24 (40%) 74 (92.5%)
Presence of OFF time at least every 3 h
 Yes 16 (26.7%) 1 (1.3%)
 No 44 (73.3%) 79 (98.7%)
Patient took at least 5 times daily oral levodopa
 Yes 34 (56.7%) 3 (3.8%)
 No 26 (43.3%) 77 (96.2%)
Level of ADL limitation capacity
 None 9 (15%) 64 (80%)
 Mild 26 (43.3%) 14 (17.5%)
 Moderate 18 (30%) 2 (2.5%)
 Severe 7 (11.7%) 0
Frequency of Falls
 None of the time 21 (35%) 67 (83.7%)
Some of the time 32 (53.3%) 13 (16.3%)
 Most of the time 6 (10%) 0
 All of the time 1 (1.7%) 0
Level of dementia
 None 27 (45%) 64 (80%)
 Mild 24 (40%) 13 (16.3%)
 Moderate 8 (13.3%) 3 (3.7%)
 Severe 1 (1.7%) 0
Level of psychosis
 None 38 (63.3%) 75 (93.8%)
 Mild 16 (26.7%) 3 (3.7%)
 Moderate 5 (8.3%) 2 (2.5%)
 Severe 1 (1.7%) 0
  1. In italic are reported the level of severity/presence of each symptoms or characteristic that must be present to consider the patient in the advanced stage according to the Delphi Panel criteria approach (5)