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Table 4 APD Delphi criteria frequency distribution in APD and non-APD patients; N (%)

From: Criteria for identification of advanced Parkinson’s disease: the results of the Italian subgroup of OBSERVE-PD observational study

 

APD (N = 60)

Non-APD (N = 80)

Severity of Motor Fluctuations

 None

9 (15%)

71 (88.8%)

 Mild

28 (46.7%)

9 (11.2%)

 Moderate

18 (30%)

0

 Severe

5 (8.3%)

0

Number of OFF hours during waking day

 None

5 (8.3%)

62 (77.5%)

 < 2 h

37 (61.7%)

17 (21.3%)

 2–4 h

11 (18.3%)

1 (1.2%)

 > 4 h

7 (11.7%)

0

Severity of night sleep disturbances

 None

10 (16.7%)

48 (60%)

 Mild

27 (45%)

24 (30%)

 Moderate

19 (31.7%)

8 (10%)

 Severe

4 (6.6%)

0

Number of hours with troublesome dyskinesia

 None

14 (23.3%)

68 (85%)

 < 2 h

19 (31.7%)

11 (13.8%)

 2–3 h

16 (26.7%)

0

  > 3 h

11 (18.3%)

1 (1.2%)

Presence of non-motor fluctuations

 Yes

36 (60%)

6 (7.5%)

 No

24 (40%)

74 (92.5%)

Presence of OFF time at least every 3 h

 Yes

16 (26.7%)

1 (1.3%)

 No

44 (73.3%)

79 (98.7%)

Patient took at least 5 times daily oral levodopa

 Yes

34 (56.7%)

3 (3.8%)

 No

26 (43.3%)

77 (96.2%)

Level of ADL limitation capacity

 None

9 (15%)

64 (80%)

 Mild

26 (43.3%)

14 (17.5%)

 Moderate

18 (30%)

2 (2.5%)

 Severe

7 (11.7%)

0

Frequency of Falls

 None of the time

21 (35%)

67 (83.7%)

Some of the time

32 (53.3%)

13 (16.3%)

 Most of the time

6 (10%)

0

 All of the time

1 (1.7%)

0

Level of dementia

 None

27 (45%)

64 (80%)

 Mild

24 (40%)

13 (16.3%)

 Moderate

8 (13.3%)

3 (3.7%)

 Severe

1 (1.7%)

0

Level of psychosis

 None

38 (63.3%)

75 (93.8%)

 Mild

16 (26.7%)

3 (3.7%)

 Moderate

5 (8.3%)

2 (2.5%)

 Severe

1 (1.7%)

0

  1. In italic are reported the level of severity/presence of each symptoms or characteristic that must be present to consider the patient in the advanced stage according to the Delphi Panel criteria approach (5)