Table 1 Demographic and clinical characteristics of children with cancer presenting in acute ischemic, hemorrhagic and cerebral sinus venous thrombosis (CSVT)
From: Stroke in Middle Eastern children with cancer: prevalence and risk factors
Characteristics | Total N=27 | Stroke type | P value | ||
|---|---|---|---|---|---|
CSVT N =16 | Hemorrhagic N =5 | Acute Ischemic N =6 | |||
Age at cancer diagnosis (years) | 9.4 (4.8-13.7) | 9.4 (5.5-14.7) | 10.6 (4.9-12.8) | 5.7 (3.6-12.7) | 0.68 |
Age at stroke diagnosis (years) | 10.6 (6.7-15.5) | 11.4 (6.1-15.7) | 10.6 (6.5-12.8) | 10.3 (6.2-16.4) | 0.92 |
Stroke onset after Cancer diagnosis: (months) | 6 (1-9) | 8 (5-9) | 1 (0.1-19) | 1.8 (0.2-39) | 0.58 |
Time to follow-up (years) | 5 (4-6) | 5 (4.3-6) | 4 (2-6) | 4.5 (2.5-7) | 0.77 |
Sex (Male) | 19 (70.4%) | 11 (68.8%) | 2 (40%) | 1 (16.7%) | 0.73 |
Cancer type | 0.001 | ||||
Brain | 7 (25.9%) | 1 (6.3%) | 1 (20%) | 5 (83.3%) | |
Leukemia | 17 (63.0%) | 14 (87.5%) | 2 (40%) | 1 (16.7%) | |
Lymphoma | 2 (7.4%) | 1 (6.3%) | 1 (20%) | 0 | |
Lung | 1 (3.7%) | 0 | 1 (20%) | 0 | |
Stroke size | 0.56 | ||||
Small | 8 (72%) | - | 4 (80%) | 4 (66.7%) | |
Large | 3 (28%) | - | 1 (20%) | 2 (33.3%) | |
Location of stroke | <0.0001 | ||||
Basal ganglia | 3 (17.6%) | - | 1 (20%) | 2 (33.3%) | |
Lobara | 4 (14.8%) | - | 2 (40%) | 2 (33.3%) | |
Posterior fossa | 4 (23.5%) | 0 | 2 (40%) | 2 (33.3%) | |
Treatment of cancer Drugs Surgical Combined | 19 (70.4%) 1 (3.7%) 7 (25.9%) | 15 (93.8%) 0 1 (6.3%) | 3 (60%) 0 2 (40%) | 1 (16.7%) 1 (16.7%) 4 (66.7%) | 0.002 |
Leukocyte count (×103 /mm3) | 6.3 (3.8-35.3) | 4.5 (3.6-51.3) | 15.3 (6-134) | 7.8 (4.5-24.2) | 0.30 |
Platelet count (×103 /mm3) | 205 (141-318) | 179 (143.8-287.3) | 170 (61.5-395) | 303.5 (207-401) | 0.147 |
Abnormal coagulation (yes) | 14 (51.9%) | 8 (50%) | 3 (60%) | 3 (50%) | 1.00 |
Stroke recurrence (yes) | 4 (19.0%) | 0 | 1 (25.0%) | 3 (60.0%) | 0.01 |
Death (yes) | 2 (7.7%) | 0 | 1 (20%) | 1 (17%) | 0.14 |