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Table 1 Demographic and clinical characteristics of children with cancer presenting in acute ischemic, hemorrhagic and cerebral sinus venous thrombosis (CSVT)

From: Stroke in Middle Eastern children with cancer: prevalence and risk factors

Characteristics Total
N=27
Stroke type P value
CSVT
N =16
Hemorrhagic
N =5
Acute Ischemic
N =6
Age at cancer diagnosis (years) 9.4 (4.8-13.7) 9.4 (5.5-14.7) 10.6 (4.9-12.8) 5.7 (3.6-12.7) 0.68
Age at stroke diagnosis (years) 10.6 (6.7-15.5) 11.4 (6.1-15.7) 10.6 (6.5-12.8) 10.3 (6.2-16.4) 0.92
Stroke onset after Cancer diagnosis: (months) 6 (1-9) 8 (5-9) 1 (0.1-19) 1.8 (0.2-39) 0.58
Time to follow-up (years) 5 (4-6) 5 (4.3-6) 4 (2-6) 4.5 (2.5-7) 0.77
Sex (Male) 19 (70.4%) 11 (68.8%) 2 (40%) 1 (16.7%) 0.73
Cancer type      0.001
  Brain 7 (25.9%) 1 (6.3%) 1 (20%) 5 (83.3%)
  Leukemia 17 (63.0%) 14 (87.5%) 2 (40%) 1 (16.7%)
  Lymphoma 2 (7.4%) 1 (6.3%) 1 (20%) 0
  Lung 1 (3.7%) 0 1 (20%) 0
Stroke size      0.56
  Small 8 (72%) - 4 (80%) 4 (66.7%)
  Large 3 (28%) - 1 (20%) 2 (33.3%)
Location of stroke      <0.0001
  Basal ganglia 3 (17.6%) - 1 (20%) 2 (33.3%)
  Lobara 4 (14.8%) - 2 (40%) 2 (33.3%)
  Posterior fossa 4 (23.5%) 0 2 (40%) 2 (33.3%)
Treatment of cancer
Drugs
Surgical
Combined
19 (70.4%)
1 (3.7%)
7 (25.9%)
15 (93.8%)
0
1 (6.3%)
3 (60%)
0
2 (40%)
1 (16.7%)
1 (16.7%)
4 (66.7%)
0.002
Leukocyte count (×103 /mm3) 6.3 (3.8-35.3) 4.5 (3.6-51.3) 15.3 (6-134) 7.8 (4.5-24.2) 0.30
Platelet count (×103 /mm3) 205 (141-318) 179 (143.8-287.3) 170 (61.5-395) 303.5 (207-401) 0.147
Abnormal coagulation (yes) 14 (51.9%) 8 (50%) 3 (60%) 3 (50%) 1.00
Stroke recurrence (yes) 4 (19.0%) 0 1 (25.0%) 3 (60.0%) 0.01
Death (yes) 2 (7.7%) 0 1 (20%) 1 (17%) 0.14
  1. aLobar: located superficially within the lobes of the brain involving the cortex but not the basal ganglia