Table 2 Definition of monophasic ADEM. From consensus definition for paediatric demyelinating disorders by Krupp et. al [1]

Clinical event with presumed inflammatory or demyelinating cause, with acute of subacute onset that affects multifocal areas of the CNS.

Clinical presentation must be polysymptomatic and must include encephalopathy

Encephalopathy is defined as one or more of the following.

 -Behavioural change e.g. confusion, irritability

 -Alteration in consciousness e.g. lethargy, coma

Clinical event followed by clinical and/ or radiological improvement with possibility of residual deficits

No history of clinical episodes with features of a prior demyelinating event