Quality of life and subjective symptom impact in Japanese patients with myotonic dystrophy type 1

BMC Neurology

Table 3 Associations between explanatory variables and overall QoL in DM1

Explanatory variable	Model 1^a		Model 2^b
	Coefficient (95% CI)	P-value	Coefficient (95% CI)	P-value
Demographic variables and functional impairment
Sex	−0.11 (− 0.47, 0.26)	0.570	0.02 (− 0.18, 0.23)	0.834
Age	0.08 (−0.14, 0.30)	0.485	−0.02 (− 0.15, 0.10)	0.722
Years of education	0.05 (−0.16, 0.26)	0.616	0.00 (−0.11, 0.12)	0.982
Disease duration	0.40 (0.20, 0.59)	< 0.001	0.12 (0.00, 0.23)	0.047
Number of CTG repeats	−0.08 (−0.29, 0.12)	0.421	−0.06 (− 0.17, 0.05)	0.317
Functional impairment	0.82 (0.40, 1.23)	< 0.001	0.31 (0.07, 0.56)	0.014
Subjective symptom impact
Weakness			0.47 (0.30, 0.64)	< 0.001
Pain			0.09 (−0.05, 0.23)	0.228
Fatigue			0.22 (0.06, 0.38)	0.009
Myotonia			0.16 (0.02, 0.29)	0.029

^a: Nagelkerke’s pseudo R² = 0.41, AIC = 195.7
^b: Nagelkerke’s pseudo R² = 0.84, AIC = 105.4
CI confidence interval, AIC Akaike information criterion, QoL quality of life

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