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Fig. 2 | BMC Neurology

Fig. 2

From: Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort

Fig. 2

The relationship between Caspase-1 rs554344 and CSF t-tau levels was mediated by CSF p-tau. The total effect of Caspase-1 rs554344 on CSF t-tau was estimated and was divided into direct effect and the mediated effect through CSF p-tau. The mediation analysis showed that CSF p-tau significantly and partially mediated the association between Caspase-1 variant and CSF t-tau levels, accounting for 80% of the total effect

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