Table 1 Demographic and clinical characteristics of included subjects in ADNI
From: Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort
Characteristics | Non-demented elderly | MCI | NC | P-value* | |||
|---|---|---|---|---|---|---|---|
Age (n, means±SD) | 698 | 73.61 ± 6.75 | 442 | 72.54 ± 7.38 | 256 | 74.80 ± 5.40 | < 0.001 |
Gender (n, male/female) | 698 | 395/303 | 442 | 266/176 | 256 | 129/127 | 0.012 |
Education (n, means±SD) | 698 | 16.05 ± 2.82 | 442 | 15.97 ± 2.85 | 256 | 16.43 ± 2.66 | 0.068 |
APOE ε4 (n, 0/1/2 alleles) | 698 | 428/225/45 | 442 | 240/163/39 | 256 | 188/62/6 | < 0.001 |
MMSE (n, means±SD) | 698 | 28.33 ± 1.61 | 442 | 27.5 ± 3.46 | 256 | 28.12 ± 5.10 | < 0.001 |
Caspase-1 rs554344 (n, GG/GC/CC) | 698 | 476/198/24 | 442 | 305/127/10 | 256 | 171/71/14 | 0.393 |
AV45 PET (n, means±SD) | 426 | 1.18 ± 0.21 | 290 | 1.21 ± 0.22 | 136 | 1.12 ± 0.18 | < 0.001 |
FDG PET (n, means±SD) | 555 | 1.27 ± 0.12 | 366 | 1.25 ± 0.13 | 189 | 1.30 ± 0.11 | < 0.001 |
CSF- Aβ42 (n, means±SD) | 410 | 918.60 ± 365.61 | 282 | 871.38 ± 349.02 | 128 | 1022.61 ± 380.92 | < 0.001 |
CSF t-tau (n, means±SD) | 516 | 262.78 ± 100.61 | 334 | 274.15 ± 109.25 | 182 | 242.60 ± 81.37 | < 0.001 |
CSF p-tau (n, means±SD) | 515 | 24.63 ± 10.79 | 333 | 26.80 ± 11.93 | 182 | 22.07 ± 8.08 | < 0.001 |
HVa (n,means±SD) | 620 | 7055.30 ± 1023.75 | 387 | 6901.99 ± 1099.49 | 233 | 7309.94 ± 825.04 | < 0.001 |