Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort

BMC Neurology

Table 2 The correlation between Caspase-1 rs554344 and CSF biomarkers, imaging data at baseline in a multiple linear regression model

Characteristics	N	Effect	CSF-Aβ₄₂ (pg/ml)	CSF t-tau (pg/ml)	CSF p-tau (pg/ml)	FDG PET (SUVRs)	AV45 PET (SUVRs)	HVa (mm³)
Non-demented elderly	698	β Coefficient	−0.217	− 0.068	−0.069	− 0.026	−0.005	118,898
Non-demented elderly	698	P-value	0.851	0.043	0.066	0.013	0.623	0.829
MCI	442	β Coefficient	−0.068	−0.100	−0.098	− 0.034	0.001	−3.196
MCI	442	P-value	0.146	0.021	0.049	0.009	0.977	0.976
NC	256	β Coefficient	93.583	0.038	0.042	−0.018	0.005	−32.772
NC	256	P-value	0.171	0.449	0.434	0.278	0.756	0.760

Abbreviation: Aβ₄₂ amyloid-β, CSF cerebrospinal fluid, HVa adjusted hippocampal volume, MCI mild cognitive impairment, N number, NC normal cognition, p-tau phosphorylated tau, t-tau total tau

ISSN: 1471-2377