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Table 1 Summary of clinical symptoms, tumor progression, and antibodies titer

From: Isaacs’ syndrome as the initial presentation of malignant thymoma and associated with double-positive voltage-gated potassium channel complex antibodies, a case report

Date

2020/04

2020/07

2020/11

Clinical

syndrome

Bilateral calf and thigh muscle cramping and twitching.

Bilateral calf and thigh muscle cramping improved.

Bilateral calf and thigh muscle twitching recurred.

LGI1a antibody titer

1:10

Negative

1:10

CASPR2b antibody titer

1:100

Negative

Negative

Chest computed tomography

Malignant thymoma (8.7 cm) with pleural and great vessel involvement.

Malignant thymoma with regression (4.5 cm).

Malignant thymoma with suspicion of post-radiation changes or progression

(5.7 cm).

High-rate (50%) repetitive nerve stimulation test

Incremental response (102%)

Normal

Nil

  1. aLGI1 leucine-rich glioma-inactivated 1
  2. b CASPR2 contactin-associated protein-like 2