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Table 1 Descriptive data of participants

From: Does COVID-19 increase the long-term relapsing-remitting multiple sclerosis clinical activity? A cohort study

Variable

Final participants (n = 53)

Mean age (SD) [years]

38.42 (8.77)

Sex (female:male)

45:8

Comorbidity (%)

None: 43 (81.13)

HTN/CV: 3 (5.66)

Hypothyroidism: 2 (3.77)

DM: 4 (7.55)

Median MS duration (IQR) [years]

10 (13)

DMT (%)

No DMT: 3 (5.66)

IFNs: 4 (7.54)

DMF: 21 (39.62)

TFN: 1 (1.89)

GA: 1 (1.89)

FNG: 12 (22.64)

RTX: 9 (16.98)

AZA: 2 (3.77)

COVID-19 diagnosis type (%)

RT-PCR: 30 (56.60)

CT: 14 (26.42)

Both: 9 (16.98)

COVID-19 severity (%)

No hospitalization: 47 (88.68)

Hospitalization: 6 (11.32)

Mean post-COVID-19 follow-up (SD) [months]

10.58 (2.48)

Outcome

Pre-COVID-19 period endpoint

Post-COVID-19 period endpoint

P value

Median EDSS (IQR)

1.5 (1)

1.5 (1)

0.08*

Number of patients with probable disability progression (%)

10 (18.87)

3 (5.66)

0.04**

Number of patients experiencing relapses (%)

16 (30.19)

11 (20.75)

0.30**

  1. *Wilcoxon signed-rank test
  2. **McNemar test
  3. Abbreviations: SD standard deviation, HTN hypertension, CV cardiovascular, DM diabetes mellitus, MS multiple sclerosis, IQR interquartile range, DMT disease-modifying therapy, IFN interferon, DMF dimethyl fumarate, TFN teriflunomide, GA glatiramer acetate, FNG fingolimod, RTX rituximab, AZA azathioprine, RT-PCR reverse transcription polymerase chain reaction, CT computed tomography, EDSS expanded disability status scale;