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Table 1 Demographic and clinical characteristics of patients by period

From: Prognostic effects of treatment protocols for febrile convulsive status epilepticus in children

 

Period I

n=26

Period II+III

n=84

p-value

Period II

n=48

Period III

n=36

p-value

Sex, male, n (%)

13 (50.0)

38 (45.2)

0.84

23 (47.9)

15 (41.7)

0.73

Age, months

16.5 (10, 29.5)

22 (16, 39.25)

0.03b

24 (15, 47.5)

20.5 (16, 35)

0.45b

History of febrile seizure, n (%)

3 (11.5)

21 (25.0)

0.18a

11 (22.9)

10 (27.8)

0.80

Temperature on admission, °C

39.1 (38.4, 39.8)

38.65 (38.1, 39.4)

0.20

38.65 (38.1, 39.4)

38.65 (38.1, 39.4)

0.69

Convulsive seizure duration

150 (96.3, 345)

133.5 (88.5, 211.3)

0.30b

125 (89.75, 210)

142.5 (84, 225.3)

0.81b

Duration of hospital stay, days

9.5 (4.75, 19.8)

7.5 (5, 13)

0.17b

7 (4, 12.3)

9 (5, 13)

0.21b

Period from onset to determination of outcome, days

26 (20, 39.8)

32 (27, 38.3)

0.84

31 (17.8, 37.8)

35.5 (30, 38.3)

0.28

EEG monitoring, n (%)

3 (11.5)

72 (85.7)

<0.001a

39 (81.3%)

33 (91.7%)

0.22a

Intubation, n (%)

15 (57.7)

41 (48.8)

0.57

23 (47.9)

18 (50.0)

1

TTM, n (%)

11 (42.3)

38 (45.2)

0.97

20 (41.7)

18 (50.0)

0.59

Vasopressor, n (%)

13 (50.0)

37 (44.0)

0.76

20 (41.7)

17 (47.2)

0.78

Number of antiepileptic drugs used

3 (2, 3)

2 (2, 3)

0.43b

2 (2, 3)

3 (2, 4)

0.07b

Details of antiepileptic drugs used

 DZP, n (%)

25 (96.2)

74 (88.1)

0.45a

44 (91.7)

30 (83.3)

0.31a

 MDL, n (%)

19 (73.1)

69 (82.1)

0.47

38 (79.2)

31 (86.1)

0.59

 fPHT iv, n (%)

0 (0)

23 (27.4)

0.002a

3 (6.3)

20 (55.6)

<0.001a

 PB, n (%)

9 (34.6)

15 (17.9)

0.12

10 (20.8)

5 (13.9)

0.59

 MDL ci, n (%)

22 (84.6)

21 (25.0)

<0.001a

19 (39.6)

2 (5.6)

<0.001a

 Thiamylal ci, n (%)

9 (34.6)

38 (45.2)

0.47

20 (41.7)

18 (50.0)

0.59

 MDL+Thiamylal ci, n (%)

9 (34.6)

10 (11.9)

0.02

10 (20.8)

0 (0)

0.004a

Time from onset to BCT initiation, h

5.5 (3.9, 37.1)

6.8 (5.0, 9.0)

0.97b

6.3 (5.3, 9.0))

6.9 (4.9, 8.9)

0.87b

  1. Data are shown as the median (interquartile range) unless otherwise noted
  2. EEG electroencephalogram, TTM targeted temperature management, DZP diazepam, MDL midazolam, fPHT fosphenytoin, PB phenobarbital, BCT barbiturate coma therapy, iv intravenous, ci continuous infusion
  3. a: Fisher's exact test
  4. b: Mann–Whitney U test
  5. others: Chi-square test for categorical variables and t-test for continuous variables