Fig. 1
From: A case report of Sanfilippo syndrome – the long way to diagnosis
Brain MRI at the age of 28 years. Transversal T2-weighted image (A) shows ventriculomegaly and enlarged cortical sulci due to brain atrophy. There is associated enlargement of the perivascular spaces (arrows). B Fluid-attenuated inversion recovery (FLAIR) sequence shows only a slight periventricular increase in signal intensity, which can be attributed to hypothetical dysmyelination. On 3D-T1-weighted images, sagittal reconstruction (C) demonstrates a thin corpus callosum and coronal reconstruction (D) shows the convincingly reduced volume of the supratentorial hemispheres, whereas the cerebellum appears normal