Fig. 1
From: Failure of alemtuzumab therapy in three patients with MOG antibody associated disease
Serial MRI changes of case 1. A & BÂ MRI brain scan (axial FLAIR sequence) and cervical spine (sagittal T2 sequence) at the time of the diagnosis of MS. Note few periventricular brain lesions and ill-defined focal areas of T2 hyperintensity at C4, C5, and C6 levels. C, D, EÂ MRI brain scan at the third relapse following Alemtuzumab therapy. Axial, sagittal, and coronal FLAIR sequences are shown here. Note bilateral large supratentorial lesions with ill-defined borders, mostly juxtacortical in location, with accompanying oedema. FÂ Axial FLAIR image of the brain following mycophenolate therapy. Note the resolution of large juxtacortical lesions seen in C,D,E leaving a few periventricular residual lesions